CELLARO CORE
The Complete 2-2-2 Longevity Routine.
VITALIZE AM ¡ RENEW PM ¡ RESET Monthly
Aging is interconnected - and most supplement stacks are not. Cellaro Core combines three clinically formulated products into one routine: morning energy support, nightly repair, and a monthly cellular reset. Complete coverage without overlaps, stacking, or guesswork.
- Morning energy & focus: VITALIZE (AM) supports NADâē and sirtuin activity for steadier daytime energy and clear focus
- Nightly repair & resilience: RENEW (PM) supports autophagy, mitochondrial health, and overnight recovery
- Monthly cellular reset: RESET delivers a short senolytic pulse to support cellular clean-up and renewal
Made in Germany ¡ GMP certified ¡ Third-party lab tested ¡ Vegan ¡ Gluten-free
There are 12 hallmarks of aging â interconnected biological processes that shape how we age. Most supplement routines target one or two in isolation, leaving gaps and creating overlap between unrelated products.
Cellaro Core is a coordinated system designed to address all 12: VITALIZE (AM) supports NADâē and sirtuin activity for daytime energy and focus, RENEW (PM) supports nightly repair, autophagy, and balanced inflammatory signaling, and RESET (Monthly) delivers a short senolytic pulse to support cellular clean-up and renewal.
Together, the three formulas form a single routine â complete coverage without overlapping ingredients, unnecessary pill burden, or guesswork. Built for consistency and measurable progress over time.
The 2-2-2 routine: a simple daily habit with a short monthly reset. Clear timing, clear roles, minimal complexity.
Morning - 2 capsules: Take VITALIZE in the morning or with your first meal to support NADâē and daytime energy.
Evening - 2 capsules: Take RENEW with dinner or before bed to support overnight repair and autophagy.
Monthly RESET - 2 days: 4 capsules per day for 2 consecutive days each month â 2 capsules in the morning and 2 in the evening.
Build the habit: Results compound with consistency. Take VITALIZE and RENEW at the same times each day, and schedule your 2-day RESET pulse in advance. Cellaro Core is designed for steady, durable change over weeks to months.
If pregnant, nursing, under 18, or taking medication, consult your healthcare professional before use. Food supplement â not a substitute for a varied diet and healthy lifestyle. Do not exceed the recommended daily dose. RESET is designed to be taken as a short pulse â do not take RESET daily.
Morning ¡ Cellular Energy
VITALIZE (AM) - UtheverÂŽ NMN, ApiAgeâĸ apigenin, resveratrol, pterostilbene, TMG
Supports the NADâē cycle and sirtuins for steady daytime energy and clear focus
A clinically studied combination designed to support NADâē levels and sirtuin activity, helping sustain energy, focus, and metabolic efficiency throughout the day.
Evening ¡ Cellular Repair
RENEW (PM) - Spermidine, LongvidaÂŽ curcumin, EGCG, astaxanthin
Supports autophagy, mitochondrial resilience, and balanced inflammatory signaling overnight
A nightly formula designed to support your body's natural repair processes â including autophagy and mitochondrial health â while helping balance everyday inflammatory signaling.
Monthly ¡ Cellular Reset
RESET - QuercefitÂŽ quercetin phytosome, fisetin, luteolin synergy
A short 2-day senolytic pulse to support cellular clean-up and tissue renewal
Three complementary flavonoids at clinically researched doses, taken as a focused monthly pulse to support the body's natural clearance of senescent cells while sparing healthy tissue.
Learn more on the Ingredient Overview page.
Free shipping on all orders.
90-day money-back guarantee. If you are not satisfied, email hello@cellaro.com within 90 days of delivery and we will refund one pouch from your first order. No return required.
Subscriptions ship monthly and can be paused or cancelled anytime from your account.
Designed around the 12 Hallmarks of Aging framework ¡ UtheverŽ, LongvidaŽ and QuercefitŽ are registered trademarks of their respective owners.
The Cellaro System
Aging is interconnected. Your routine should be too.
The 12 hallmarks of aging are interconnected, so Cellaro's ingredients are chosen to work together.
The Core Routine addresses all 12 in one simple system that's easy to maintain.
No guesswork. No overlap. No gaps.
Explore the 12 Hallmarks
Complete, not complicated.
The Cellaro 2-2-2 Routine
Complete, not costly.
Twelve research-backed ingredients, sourced separately, would cost more than double. And you'd still be left to figure out the doses, the timing, and the stacking yourself.
12 separate supplements, 12 separate bottles, 12 sets of doses and timing to keep track of.
The same 12 ingredients, pre-dosed and pre-paired into one simple AM / PM / monthly routine.
See the full price breakdown
DIY pricing reflects the cost of sourcing each ingredient individually at its commonly recommended daily dose from reputable single-ingredient suppliers (incl. DoNotAge, Double Wood, ProHealth, NOW Foods), converted to EUR. Figures are estimates for illustrative comparison and may vary by retailer, region, and exchange rate.
Track your progress.
Once your routine is in place, here's how to start watching it work, in your data and your bloodwork.
What to look for, and how to measure change over time.
- HRV (nightly)
- Resting heart rate
- Sleep quality (efficiency and deep-sleep minutes)
- Readiness / recovery score
- NAD+ (whole blood)
- hs-CRP (inflammation)
- HOMA-IR (insulin sensitivity)
- A1c (3-month glucose)
- TG/HDL ratio (metabolic health)
- Baseline: week 0 (7-day average)
- First signs: week 4
- Best read: after 3 months
- Baseline: week 0
- NAD+: 4-8 weeks
- Other markers: 4-6+ months
These are general guidelines for noticing change over time, not medical advice. Speak with your doctor before starting any new testing routine, especially if you take medication or have an existing health condition.
Our Ingredients
Clinically studied. Backed by science.
Vitalize ¡ AM
UtheverÂŽ NMN
Directly raises NAD+ levels, the molecule your cells rely on for energy production and repair. Clinically studied, over 99% pure.
Explore
Renew ¡ PM
Spermidine
Drives autophagy, your body's natural process for clearing and renewing damaged cells, supporting long-term cellular resilience.
Explore
Renew ¡ PM
LongvidaÂŽ Curcumin
Sustained anti-inflammatory support that helps create the right conditions for overnight repair and mitochondrial renewal.
Explore
Reset ¡ Monthly
QuercefitÂŽ Quercetin
A phytosome form of quercetin built for significantly higher absorption. Works alongside fisetin to support healthy inflammatory and oxidative balance.
ExploreFrequently asked questions
Straightforward answers about how the Cellaro Core works, what to expect, and how it fits into your routine.
VITALIZE (AM) supports NAD+ levels, cellular energy, and daytime resilience. RENEW (PM) supports autophagy, mitochondrial health, and overnight cellular repair. RESET (Monthly) is a short, focused two-day pulse that helps clear senescent cells.
Rather than three isolated supplements, the Core is timed around your circadian rhythm and designed for consistency and long-term progress.
As we age, NAD+ declines, inflammation rises, and damaged cells accumulate. The Core addresses these three shifts directly. VITALIZE supports NAD+ and daytime cellular energy, RENEW supports nightly repair and inflammation balance, and RESET helps clear the senescent cells that build up over time.
Splitting VITALIZE (AM) and RENEW (PM) lets each formula support what your cells are already doing at that time of day. It also keeps your daily pill count low and makes the routine easier to stick to.
RESET is taken for two consecutive days each month so it can target dysfunctional cells while sparing healthy tissue. For most people, one pulse a month is enough. During higher-stress periods, some choose a second pulse around days 15 to 16, within label guidance.
The Cellaro Core brings all twelve into one coordinated AM, PM, and monthly routine for EUR 175 a month, dosed in the ratios used in our formulas. Same ingredients, far less guesswork, far fewer bottles.
You can track progress two ways. With a wearable, HRV, resting heart rate, and sleep quality typically shift first, often by week four. With bloodwork, NAD+ can be retested at four to eight weeks, with markers like hs-CRP and HOMA-IR best checked after three to six months.
You can adjust timing during travel, illness, or high-stress periods. Consistency over time matters more than daily perfection.
For VITALIZE, most people start with two capsules a day. Once you have found what feels right, some adjust to one capsule a day depending on training load, stress, sleep, and lifestyle, while others continue with two.
For RESET, most people follow one two-day pulse a month, with some adding a second pulse during higher-stress months.
If you miss a day, simply continue as planned. There is no need to double up. The routine is meant to adapt to your life, not the other way around.
Longevity Insights
Inflammagingâ How quiet inflammation accelerates aging
Senescence 101 - How senescent âzombie cellsâ affect aging
Key clinical studies and references
Cellular aging and senescence
- Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nature Reviews Molecular Cell Biology. 2007;8(9):729 to 740. View on PubMed
- Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. The Journals of Gerontology: Series A. 2014;69(Suppl 1):S4 to S9. View on PubMed
- Childs BG, et al. Senescent cells: an emerging target for diseases of ageing. Nature Reviews Drug Discovery. 2017;16(10):718 to 735. View on PubMed
NAD+ biology and energy (VITALIZE)
- Imai S-I, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 2014;24(8):464 to 471. View on PubMed
- Nakahata Y, Sahar S, Astarita G, et al. Circadian control of the NAD+ salvage pathway by CLOCKâSIRT1. Science. 2009;324(5927):654 to 657. View Study
- Ramsey KM, Yoshino J, Brace CS, et al. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science. 2009;324(5927):651 to 654. View Study
NMN supplementation and metabolic outcomes (VITALIZE)
- Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224 to 1229. View Study
- Irie J, Inagaki E, Fujita M, et al. Effect of oral NMN on clinical parameters in healthy men. Endocrine Journal. 2020;67(2):153 to 160. View Study
- Yi L, Maier AB, Tao R, et al. Efficacy and safety of beta-NMN supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled trial. GeroScience. 2023;45(1):29 to 43. View Study
- Huang H. Efficacy and safety of Uthever NMN supplementation in middle-aged and older adults. Frontiers in Aging. 2022;3:851698. View Study
NMN transport and NAD+ metabolism (VITALIZE)
- Grozio A, Mills KF, Yoshino J, et al. SLC12A8 is a nicotinamide mononucleotide transporter. Nature Metabolism. 2019;1:362 to 370. View Study
- Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins. Annual Review of Nutrition. 2008;28:115 to 130. View Study
CD38 inhibition and NAD+ preservation (VITALIZE)
- Escande C, Nin V, Price NL, et al. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38. Diabetes. 2013;62(4):1084 to 1093. View Study
- Ogura Y, Kitada M, Xu J, et al. CD38 inhibition by apigenin restores intracellular NAD+/NADH ratio and SIRT3 activity. Aging (Albany NY). 2020;12(12):11325 to 11336. View Study
Methylation support and NAD+ recycling (VITALIZE)
- Williams EG, et al. An introduction to systems genetics. Journal of Biological Chemistry. 2012. View Study
- Bhasin S, et al. NAD+ metabolism and the requirement for methylation support. Nature Metabolism. 2023. View Study
- Steenge GR, Verhoef P, Katan MB. Betaine supplementation lowers plasma homocysteine in healthy men and women. American Journal of Clinical Nutrition. 2001;74(1):136 to 138. View Study
Autophagy and cellular recycling (RENEW)
- Ohsumi Y. Discovery of autophagy genes and the cellular recycling pathway. Nobel Prize in Physiology or Medicine. 2016. Press release | Advanced information
- Rubinsztein DC, et al. Autophagy and aging. Cell (Review). View on PubMed
- Ma D, et al. Circadian control of autophagy: clock genes regulate daily autophagy rhythms. Proceedings of the National Academy of Sciences (PNAS). PMC | PubMed
EGCG, autophagy and antioxidant protection (RENEW)
- Zhou J, et al. EGCG increases autophagosome formation and autophagic flux via AMPK involvement. Journal of Nutritional Biochemistry. PubMed | PMC
Curcumin and inflammation balance (RENEW)
- McFarlin BK, et al. Longvida curcumin (400 mg/day) reduces rises in inflammatory and CK markers in a 4-day recovery model versus placebo (human study). Journal of Dietary Supplements. PubMed | PMC
- Nelson KM, et al. Curcumin formulation review: third-generation strategies (including SLCP/Longvida) improve systemic and free curcumin availability. Pharmaceutics. PMC
- Gota VS, et al. Longvida/SLCP human pharmacokinetics: free curcumin detectable in plasma; improved exposure versus conventional forms. Journal of Agricultural and Food Chemistry. PubMed
Astaxanthin and oxidative defense (RENEW)
- Zhang L, et al. Astaxanthin meta-analysis (2022): reductions in oxidative-stress and inflammation biomarkers (human studies). Nutrients. PubMed
- Yuan JP, et al. Astaxanthin meta-analysis (2020): antioxidant effects versus control; trend toward lower MDA. Marine Drugs. PubMed
Spermidine and cellular longevity (RENEW)
- Kiechl S, et al. Spermidine intake and mortality in the Bruneck cohort: higher dietary intake associated with lower mortality over approximately 20 years. American Journal of Clinical Nutrition. PubMed
- Madeo F, et al. Spermidine and aging: review. Levels decline with age; exogenous spermidine reverses age-associated cellular changes (preclinical and early clinical evidence). Aging (Albany NY). PMC
Circadian rhythm and evening light exposure
- Chang AM, et al. Evening light-emitting eReaders suppress melatonin, delay circadian timing, and reduce next-morning alertness. Proceedings of the National Academy of Sciences (PNAS). PubMed | PNAS
Senolytics and senescent cell clearance (RESET)
- Baker DJ, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011;479(7372):232 to 236. View on PubMed
- Kirkland JL, Tchkonia T. Senolytic drugs: from discovery to translation. Journal of Internal Medicine. 2020;288(5):518 to 536. View Study
- Zhu Y, et al. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell. 2016;15(3):428 to 435. View Study
Human senolytic intervention studies (RESET)
- Justice JN, et al. Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label pilot study. EBioMedicine. 2019;40:554 to 563. View on PubMed
- Hickson LJ, et al. Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease. EBioMedicine. 2019;47:446 to 456. View on PMC
- Nambiar A, et al. Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results from a randomized pilot trial. EBioMedicine. 2023. View on PubMed
Fisetin (RESET)
- Yousefzadeh MJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18 to 28. View on PubMed
- Khan N, et al. Fisetin: a dietary antioxidant for health promotion. Antioxidants and Redox Signaling. 2013;19(2):151 to 162. View Study
- AFFIRM Frailty Trial (ongoing). Fisetin in older adults. ClinicalTrials.gov NCT03675724
Quercetin and Quercefit (RESET)
- Di Pierro F, et al. Quercefit (quercetin phytosome): enhanced bioavailability (approximately 20x) and improvements in antioxidant and inflammation markers. Minerva Medica. 2019;110(7):524 to 533. View on PubMed
- Riva A, et al. Improved oral absorption of quercetin from quercetin phytosome in healthy subjects. European Journal of Drug Metabolism and Pharmacokinetics. 2019;44(2):169 to 177. View Study
Luteolin (RESET)
- Kou X, et al. Luteolin alleviates oxidative stress and cellular senescence via SIRT1/p53 pathway modulation. Free Radical Biology and Medicine. 2017;106:20 to 30. View on PubMed
- Luo Y, et al. Luteolin ameliorates neuroinflammation and memory impairment through microglial modulation. Frontiers in Aging Neuroscience. 2017;9:254. View on PubMed
Bioavailability enhancement across the system
- Singh A, et al. Enhanced oral bioavailability of quercetin with piperine co-administration: preclinical evidence. Pharmacognosy Magazine. 2017;13(Suppl 2):S250 to S256. View on PMC
- Shoba G, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica. 1998;64(4):353 to 356. View on PubMed
- Tripathi S, et al. Piperine as a bioenhancer: a review of preclinical and clinical pharmacokinetic evidence. European Journal of Drug Metabolism and Pharmacokinetics. 2022;47(2):127 to 141. View on PMC
Skin aging and cellular senescence
- Waaijer M, et al. The number of p16INK4a-positive cells is increased in aged human dermis. Aging Cell. 2012;11(4):722 to 725. View Study
- Pilkington S, et al. Senescent fibroblasts accumulate in human skin with aging and impair the tissue environment. Journal of Investigative Dermatology. 2021. View Study
- Wlaschek M, Scharffetter-Kochanek K. Senescent dermal fibroblasts and the aging skin extracellular matrix. Journal of Investigative Dermatology. 2021. View Study
The Core Routine
From 1,657 kr/month ¡ 90-day guarantee