During sleep, the body repairs and renews cells. RENEW supports this process by promoting autophagy, mitochondrial maintenance, and cellular protection overnight.
Nightly cellular clean-up (autophagy)
Cellular repair and overnight recovery
Overnight antioxidant cellular protection
Long-term cellular renewal and resilience
Night is when your body does most of its repair. With age, repair slows, everyday inflammatory stress (“inflammaging”) rises, and natural spermidine production declines. Autophagy—your cells’ clean-up and recycle mode—can drift off schedule, so wear-and-tear lingers, next-day energy dips, and recovery lags.
RENEW takes a complete night approach: it supports autophagy/mitophagy, supports mitochondrial maintenance, and adds antioxidant defense to help lower everyday inflammatory stress—so night repair can finish and carry into tomorrow.
Sleep-friendly actives (behind the scenes):
• Longvida® Curcumin + EGCG help engage renewal pathways (autophagy/AMPK) and mitochondrial upkeep.
• Spermidine helps trigger and sustain cellular clean-up (autophagy/mitophagy).
• Astaxanthin adds membrane-focused antioxidant protection during the sleep window.
Simple night routine. No overthinking.
Clean-up → Recharge → Protect
Pair with VITALIZE: By day, VITALIZE supports NAD⁺/sirtuins for energy and daytime defense; at night, RENEW supports clean-up, mitochondrial maintenance, and night protection for a simple 24-hour rhythm.
Note: RENEW isn’t a sleep aid. It pairs well with magnesium (relaxation). Decaffeinated EGCG; not a stimulant.
How to take
Take 2 capsules in the evening with your main meal or ~60 minutes before bed.
Sensitive stomach? Take with food. Fasting? Take with your last meal. Aim for the same time each night.
Why night
Your body prioritizes repair during sleep. Taking RENEW at night aligns support for autophagy/mitophagy, mitochondrial maintenance, and antioxidant defense.
Lifestyle protocol (night routine)
• Evening meal: take RENEW; include protein for repair; hydrate for clearance.
• Wind-down: low light 1–2 h; screens off 30–60 min; avoid late alcohol—cues deeper sleep.
• Sleep window: consistent schedule; aim for 7+ hours for deeper repair.
Pairing
AM VITALIZE + PM RENEW = the essential cellular routine
Day: NAD⁺/sirtuins (energy, daytime defense)
Night: autophagy, mitochondrial maintenance, night antioxidant protection
Safety
RENEW isn’t a sleep aid. Magnesium can support relaxation; melatonin is a timing cue. You may take them with RENEW. If you use medication or have a condition, consult your clinician. (Decaffeinated EGCG.)
Allergens & suitability
Contains wheat (gluten) from wheat-germ extract (spermidine). Not suitable during pregnancy or breastfeeding.
Note
Do not exceed the recommended daily dose. Food supplements are not a substitute for a varied diet and healthy lifestyle. Keep out of reach of children. Store in a cool, dry place away from sunlight.
Clinically studied ingredients
Together they support night repair—clean up, recharge, protect—so you wake feeling more restored and support cellular renewal over time.
Why it works
Built for the sleep window: clean up, recharge, protect—so you wake ready and support cellular renewal over time.
What the evidence shows (by ingredient)
Human clinical work on bioavailable curcumin shows favorable shifts in inflammatory/oxidative-stress markers. Preclinical and early human research indicates spermidine and EGCG engage autophagy-linked pathways and mitochondrial quality control, while astaxanthin provides membrane-focused antioxidant defense. RENEW brings these threads together into a simple PM routine.
Pair with VITALIZE
AM VITALIZE + PM RENEW = a simple 24-hour cellular rhythm.
Day: NAD⁺/sirtuins for energy and daytime defense.
Night: autophagy, mitochondrial maintenance, PM protection (decaf EGCG).
Longvida® Optimized Curcumin® is the registered trademark of Verdure Sciences Inc. Patents: www.vs-corp.com/ip
Shipping
Worldwide delivery — 3–10 business days from dispatch (varies by region). See Shipping & Returns.
90 Day Guarantee
We’re confident you’ll feel the difference. Results build over 2–3 months. If you’re not satisfied, email support@cellaro.com within 90 days of delivery and we’ll refund one pouch from your first order — no return required.
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Made in Germany
Clinically studied ingredients
Third-Party Tested for Purity
Multi-Active Formulas
How RENEW Works
Clean Up
Supports autophagy/mitophagy so nightly repair can finish.
Recharge
Helps maintain mitochondrial function and repair signalling for steadier mornings.
Reduce & Protect
Balances everyday inflammatory signals and adds PM antioxidant defence.
Cellular Renewal
Supports cellular rejuvenation with consistent PM use.
Why autophagy earned a Nobel Prize
Autophagy is your cell’s clean-up and recycle program. Every day, normal activity leaves behind cellular damage. When autophagy runs well, those leftovers are cleared and cells are renewed.
As we age, autophagy slows and low-grade inflammaging rises. More build-up lingers, making mitochondria work harder for the same output. That extra effort means heavier mornings, lower energy and slower recovery.
Think of a car tire slowly losing air. You can still drive, but every kilometer takes more effort and fuel; the ride feels heavy and rough. Keep going and eventually you can’t move at all. Efficient autophagy is like reinflating the tire—remove the drag, restore smooth rolling, and the same effort carries you farther.
Our Ingredients
Clinically studied. Built for nightly cellular repair.
Spermidine
Drives autophagy — your body’s natural process of clearing and renewing damaged cells — promoting long-term cellular resilience.
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Longvida® Curcumin
Sustained anti-inflammatory action — helps create an optimal overnight environment for autophagy, repair, and mitochondrial renewal.
Explore
EGCG
Polyphenol that supports autophagy — helps protect cells and clear oxidative damage during overnight cellular renewal. Decaffeinated.
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Astaxanthin
Protects mitochondria, cell membranes, and skin collagen from oxidative stress — supporting resilience, recovery, and youthful skin.
ExploreSmarter Together: Synergy in Night Repair
Lighter mornings
Autophagy support begins
Daytime energy more even
Repair strengthens
Nightly repair more efficient
Inflammatory tone eases
Compounded gains
Repair rhythm stabilized
Enhanced cellular function
Build Your Longevity Routine
For foundational cellular health and repair
For skin renewal, glow and deeper cellular repair
For better recovery and long-term cellular health.
Longevity insights for cellular repair
Cellaro RENEW is a nightly supplement designed to support cellular repair during sleep. It works with the body’s natural night-time repair window to support autophagy, mitochondrial maintenance, and antioxidant defence—helping recovery, resilience, and long-term cellular health.
No. RENEW is not a sleep supplement or sedative. It supports the biological repair processes that occur during sleep, without inducing drowsiness.
No. RENEW isn’t sedating and contains no stimulants. It uses decaffeinated green tea extract (EGCG); any residual caffeine is negligible. Most people report lighter mornings and steadier recovery, not drowsiness. If you’re sensitive to night supplements, take RENEW earlier in the evening or with a small snack.
Take RENEW in the evening, around the same time daily. With or without food is fine; if your stomach is sensitive, take with a small snack. Consistency matters more than the exact minute. For best results, keep late heavy meals and alcohol in check on weeknights.
Magnesium supports relaxation, and melatonin signals sleep timing. RENEW targets cellular night-time maintenance—autophagy, mitophagy, mitochondrial support, and antioxidant protection—so you wake with less physiological drag. It is not a sedative.
Yes. RENEW pairs well with magnesium; use any form/timing that suits you. Melatonin can be used occasionally (e.g., jet lag); keep doses modest. If you take prescription medicines or have a medical condition, check with your clinician before use.
Expect subtle shifts in weeks 2–4 (smoother recovery, easier mornings), with more consistent changes by 8–12 weeks. Responses vary by sleep, training, age, and stress. Daily use matters more than timing—keep your evening routine steady while you evaluate.
RENEW is for healthy adults. Do not use if pregnant or breastfeeding. If you take prescription medicines—especially anticoagulants—review the ingredient list with your clinician. Contains wheat-derived ingredients and gluten; avoid if you’re gluten-free or have a wheat allergy.
Look at weekly trends, not single nights. Useful signals: HRV, resting heart rate, awakenings, sleep efficiency/deep sleep, and your readiness/recovery score. Record a 7-day baseline (Week 0), check again at 4–8 weeks, and expect the clearest trend by ~3 months of consistent use.
Yes. Many people use VITALIZE (AM) for daytime cellular energy, RENEW (PM) for night-time repair, and RESET periodically as a short pulse. Each targets a different biological lever.
For skin support, RENEW can be taken alongside BOOST, which provides daily dermal nutrition. BOOST supports collagen quality, hydration, and barrier function during the day, while RENEW supports cellular clean-up and repair overnight. Follow each product’s label.
[1] Ohsumi Y. Discovery of autophagy genes and the cellular recycling pathway. Nobel Prize in Physiology or Medicine, 2016. Press release | Advanced information
[2] Rubinsztein DC, et al. Autophagy and aging. Cell (Review). PubMed
[3] Ma D, et al. Circadian control of autophagy: clock genes regulate daily autophagy rhythms. Proceedings of the National Academy of Sciences (PNAS). PMC | PubMed
[4] Zhou J, et al. EGCG increases autophagosome formation and autophagic flux via AMPK involvement. Journal of Nutritional Biochemistry. PubMed | PMC
[5] McFarlin BK, et al. Longvida® curcumin (400 mg/day) reduces rises in inflammatory and CK markers in a 4-day recovery model versus placebo (human study). Journal of Dietary Supplements. PubMed | PMC
[6] Nelson KM, et al. Curcumin formulation review: third-generation strategies (including SLCP/Longvida®) improve systemic and free curcumin availability. Pharmaceutics. PMC
[7] Gota VS, et al. Longvida®/SLCP human pharmacokinetics: free curcumin detectable in plasma; improved exposure versus conventional forms. Journal of Agricultural and Food Chemistry. PubMed
[8] Zhang L, et al. Astaxanthin meta-analysis (2022): reductions in oxidative-stress and inflammation biomarkers (human studies). Nutrients. PubMed
[9] Yuan JP, et al. Astaxanthin meta-analysis (2020): antioxidant effects versus control; trend toward lower MDA. Marine Drugs. PubMed
[10] Kiechl S, et al. Spermidine intake and mortality in the Bruneck cohort: higher dietary intake associated with lower mortality over ~20 years. American Journal of Clinical Nutrition. PubMed
[11] Madeo F, et al. Spermidine and aging — review: levels decline with age; exogenous spermidine reverses age-associated cellular changes (preclinical and early clinical evidence). Aging (Albany NY). PMC
[12] Chang AM, et al. Evening light-emitting eReaders suppress melatonin, delay circadian timing, and reduce next-morning alertness. Proceedings of the National Academy of Sciences (PNAS). PubMed | PNAS
