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RENEW

Your Nightly Cellular Repair.

Backed by Nobel Prize-recognized research on autophagy.

2 capsules nightly ¡ 30-day supply ¡ Timed for your sleep window

When repair slows, aging accelerates. And you feel it.

  • Clear the damage from your day: autophagy removes cellular debris while you sleep. What doesn't get cleared, accumulates.
  • Wake up more restored: when repair runs without interference you notice it in how you feel the next morning. Less drag, steadier energy.
  • Support how your body ages over time: nightly repair compounds. Getting it right consistently is what shifts long-term cellular health.

"I train 5 days a week. After about three weeks of taking RENEW, my soreness the morning after hard sessions was noticeably less. Recovery stopped being the limiting factor."

Erik S. ¡ 41 ¡ Verified Customer

"I take VITALIZE in the morning and RENEW at night. It just makes sense. Energy in the day, repair at night. I feel like I'm actually working with my body now instead of just getting through it."

Maja L. ¡ 35 ¡ Verified Customer

"I didn't notice a dramatic change. I just started waking up without the heaviness I'd gotten used to. Clearer head, less stiffness. Took about a month. I only noticed when I ran out and it came back."

Oscar M. ¡ 52 ¡ Verified Customer

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Made in Germany ¡ GMP certified ¡ Third-party lab tested ¡ Contains gluten (wheat germ extract). Not suitable during pregnancy or breastfeeding.

Night is when your body does its most important repair work. With age, three things go wrong: autophagy slows, background inflammation rises, and cells become more vulnerable to oxidative damage during the repair process itself.

RENEW supports all three. Spermidine triggers autophagy — your cells' clean-up and recycling cycle, linked to Nobel Prize-recognized research. Longvida® curcumin and EGCG help balance inflammation so repair is not actively sabotaged while it runs. Astaxanthin protects mitochondria and cell membranes from oxidative stress during the rebuilding window.

The result: a nightly system that helps your body finish what it starts while you sleep.

No. Fasting triggers autophagy by reducing insulin and mTOR through caloric restriction. Spermidine triggers autophagy through a completely different mechanism — epigenetic signaling, independently of what you ate. They work through separate pathways and are additive, not interchangeable.

RENEW means you get autophagy support every night, not just on days you fast. If you do fast, the effects may be stronger. If you do not, RENEW still provides meaningful nightly support. It is not a replacement for a healthy lifestyle — it works alongside it.

Take 2 capsules in the evening, around the same time each night. With or without food is fine. If your stomach is sensitive, take with a small snack. Aim for consistency more than precision.

Why evening: your body's repair processes are most active during sleep. Taking RENEW at night aligns autophagy support, inflammation balance, and antioxidant protection with your body's natural overnight repair window.

Pair with VITALIZE: VITALIZE in the morning supports NAD+ and cellular energy. RENEW at night supports repair, autophagy, and inflammation balance. Together they create a simple 24-hour cellular rhythm.

RENEW is not a sleep aid. Contains decaffeinated EGCG. Not suitable during pregnancy or breastfeeding. Contains wheat (gluten). If you take prescription medication, consult your doctor before use.

Autophagy trigger

Spermidine (wheat germ extract) — 400 mg · providing 4 mg spermidine

Triggers and sustains autophagy — the cell's nightly clean-up cycle

Spermidine is produced naturally by the body and microbiome but declines with age. It triggers autophagy through epigenetic signaling — independently of caloric restriction. Higher dietary spermidine is associated with lower mortality across ~20 years of follow-up (Kiechl et al., American Journal of Clinical Nutrition). Contains wheat (gluten).

Inflammation balance

Longvida® Optimized Curcumin — 400 mg

Controls inflammation so repair can complete without interference

Standard curcumin is poorly absorbed. Longvida® uses a patented lipid delivery system (SLCP) that makes free curcumin detectable in plasma — dramatically improving bioavailability. Human studies show favorable shifts in inflammatory markers. Without inflammation control, autophagy runs but repair remains incomplete. Longvida® is a registered trademark of Verdure Sciences Inc.

Autophagy reinforcement

Green Tea Extract EGCG — 100 mg (decaffeinated)

Reinforces autophagy and supports mitochondrial quality control

EGCG activates AMPK, one of the key switches that turns on autophagy. It also supports mitochondrial function and provides antioxidant protection during the repair window. Decaffeinated — no stimulant effect. Works synergistically with spermidine to extend and reinforce the autophagy signal.

Cell protection during repair

Astaxanthin (natural microalgae) — 10 mg

Protects mitochondria and cell membranes from oxidative damage while repair runs

The repair process itself generates oxidative stress. Astaxanthin is one of the most potent natural antioxidants, crossing the blood-brain barrier and anchoring into cell membranes. It protects the very structures being rebuilt during the overnight window. Human meta-analyses show reductions in oxidative stress and inflammatory biomarkers.

Free EU shipping on all orders. Worldwide delivery typically 3 to 10 business days, varies by region.

90-day money-back guarantee. If you are not satisfied, email hello@cellaro.com within 90 days of delivery and we will refund one pouch from your first order. No return required.

Subscriptions ship monthly and can be paused or cancelled anytime from your account.

LongvidaŽ Optimized CurcuminŽ is a registered trademark of Verdure Sciences Inc. ¡ Autophagy research recognised by the 2016 Nobel Prize in Physiology or Medicine.

Nobel Prize-recognized research 2016 Nobel Prize in Physiology or Medicine
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LongvidaÂŽ curcumin Superior bioavailability vs standard curcumin
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Spermidine from wheat germ Linked to lower mortality in 20-year human study
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Three pathways. One formula. Autophagy ¡ Inflammation balance ¡ Cell protection
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Nobel Prize-recognized research 2016 Nobel Prize in Physiology or Medicine
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LongvidaÂŽ curcumin Superior bioavailability vs standard curcumin
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Spermidine from wheat germ Linked to lower mortality in 20-year human study
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Three pathways. One formula. Autophagy ¡ Inflammation balance ¡ Cell protection
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Night sky — cellular repair happens during sleep
Why repair slows with age

Three things slow repair with age. All three need to be addressed.

Autophagy slows

Damaged cellular components accumulate instead of being cleared. The backlog grows every night. What your cells cannot clear, they carry forward.

Inflammation rises

Elevated inflammaging does not just slow repair. It actively sabotages it while it runs. Repair starts but cannot finish in a hostile cellular environment.

Cells become more vulnerable

Oxidative stress damages the structures being rebuilt before repair can finish. The more damage during repair, the less the net gain each night.

RENEW supports all three. That is why it works differently.

RENEW PDP - Overnight Repair (How It Works)
Cellaro RENEW pouch, nightly support for cellular repair and protection
Overnight Repair

Give your cells what they need overnight.

A coordinated system that supports repair while you sleep.

01

Spermidine: clears the damage

Removes damaged cellular components so repair can begin.

02

Curcumin: keeps the environment stable

Balances inflammation so repair can happen efficiently.

03

EGCG: reduces cellular stress

Helps maintain the conditions needed for repair.

04

Astaxanthin: protects during repair

Defends cells from oxidative stress while rebuilding takes place.

RENEW PDP - Journey / What to Expect
What to expect

What happens after you start RENEW.

01
Month 1

Repair signals activate.

  • Sleep quality may start to shift
  • Early signs of recovery appear
  • Mornings can feel a little easier

Many people notice subtle changes first. This is a good time to start tracking trends in HRV, so you have a baseline to compare against.

02
Months 2 to 3

Repair efficiency strengthens.

  • Inflammation levels begin to stabilize
  • Recovery becomes more consistent
  • Sleep and energy feel steadier

This is a good window to retest hs-CRP, around 12 weeks in, to see how your inflammation markers have shifted.

Retest hs-CRP
03
Months 4 to 6

Cellular stability builds.

  • Longer-term trends become visible
  • Metabolic markers continue to shift
  • Repair feels like part of your routine

Look for changes in metabolic measurements like HbA1c and triglycerides. These shifts build over months, not weeks.

RENEW PDP - Cell Biology Explainer (Autophagy)

Autophagy

Autophagy is the cell's clean-up and recycling system.

Every day, normal activity creates cellular damage. Autophagy is your cells' clean-up process, clearing out damaged components so they can keep functioning and repairing themselves.

As you age, this process becomes less efficient, and damage starts to accumulate.

RENEW supports autophagy through spermidine, one of the most studied compounds linked to cellular recycling and repair.

RENEW PDP - Backed by Research

Backed by research

Grounded in research on autophagy, cellular repair and inflammation biology.

Review the research
RENEW PDP - Cell Biology Explainer (Inflammation)

Inflammation

Inflammation levels tend to rise with age and ongoing cellular stress.

When inflammation remains elevated, it can interfere with normal cellular maintenance and repair.

RENEW includes curcumin, EGCG and astaxanthin, compounds widely studied for their role in supporting balanced inflammatory responses.

RENEW PDP - Our Ingredients
The Formula

Our Ingredients

Four compounds supporting overnight cellular repair.

Spermidine sourced from wheat germ Autophagy

Spermidine

Supports autophagy, your cells' natural recycling process for clearing out damaged components and renewing themselves overnight.

Explore
Longvida curcumin root Inflammation Balance

LongvidaÂŽ Curcumin

Helps balance inflammation levels overnight, creating favorable conditions for cellular repair while you sleep.

Explore
EGCG green tea leaves Antioxidant Protection

EGCG

A green tea polyphenol that helps protect cells and clear oxidative damage during overnight cellular renewal.

Explore
Astaxanthin algae source Oxidative Defense

Astaxanthin

A potent antioxidant that helps protect cells from oxidative stress, supporting recovery while you rest.

Explore
RENEW PDP - FAQ
Questions

RENEW: frequently asked questions

Straightforward answers about how RENEW works, how to take it, and what to expect.

Cellaro RENEW is a nightly supplement designed to support cellular repair during sleep. It works with your body's natural overnight repair window to support autophagy, mitochondrial maintenance, and antioxidant defense, helping you wake up with better recovery, resilience, and long-term cellular health.
No to both. RENEW is not a sleep aid or sedative, and it will not make you drowsy. It supports the biological repair processes that already happen while you sleep, rather than changing how you fall asleep.

RENEW uses decaffeinated green tea extract (EGCG), so any residual caffeine is negligible. Most people notice lighter mornings and steadier recovery, not drowsiness. If you are sensitive to evening supplements, take RENEW earlier in the evening or with a small snack.
Magnesium supports relaxation, and melatonin signals your body that it is time to sleep. RENEW works differently. It targets cellular night-time maintenance, including autophagy, mitophagy, mitochondrial support, and antioxidant protection, so you wake with less physiological drag.

It is not a sedative, and it does not change when or how easily you fall asleep.
Take RENEW in the evening, around the same time each day. With or without food is fine, though if your stomach is sensitive, take it with a small snack. Consistency matters more than the exact minute.

For best results, try to keep late, heavy meals and alcohol in check on weeknights. Both can work against the repair processes RENEW is designed to support.
Yes. RENEW pairs well with magnesium, in whatever form and timing suits you. Melatonin can be used occasionally, for example during jet lag, but is best kept to modest doses.

If you take prescription medicines or have a medical condition, check with your clinician before combining supplements.
Most people notice subtle shifts within two to four weeks, like smoother recovery and easier mornings, with more consistent changes by eight to twelve weeks. Responses vary depending on sleep, training, age, and stress.

Daily use matters more than exact timing. Keep your evening routine steady while you evaluate.
Look at weekly trends rather than single nights. The most useful signals are HRV, resting heart rate, awakenings, sleep efficiency and deep sleep, and your readiness or recovery score.

Record a seven-day baseline in week one, check again at four to eight weeks, and expect the clearest trend after about three months of consistent use.
Yes. Many people use VITALIZE (AM) for daytime cellular energy, RENEW (PM) for overnight repair, and RESET periodically for a short senolytic pulse. Each targets a different part of the aging process, and together they form the Cellaro Core routine.

For skin support, RENEW pairs well with BOOST, which provides daily dermal nutrition. BOOST supports collagen quality, hydration, and barrier function during the day, while RENEW supports cellular clean-up and repair overnight. Follow the label for each product.
RENEW is formulated for healthy adults and is not appropriate during pregnancy or breastfeeding. If you take prescription medicines, especially anticoagulants, review the ingredient list with your clinician before use.

RENEW contains wheat-derived ingredients and gluten, so it is not suitable if you are gluten-free or have a wheat allergy.

Longevity insights for cellular repair

RENEW References

Key clinical studies & references

Autophagy and cellular repair

  1. Ohsumi Y. Discovery of autophagy genes and the cellular recycling pathway. Nobel Prize in Physiology or Medicine. 2016. Press release | Advanced information
  2. Rubinsztein DC, et al. Autophagy and aging. Cell (Review). View on PubMed
  3. Ma D, et al. Circadian control of autophagy: clock genes regulate daily autophagy rhythms. Proceedings of the National Academy of Sciences (PNAS). PMC | PubMed

EGCG (green tea polyphenol)

  1. Zhou J, et al. EGCG increases autophagosome formation and autophagic flux via AMPK involvement. Journal of Nutritional Biochemistry. PubMed | PMC

Curcumin and inflammation balance

  1. McFarlin BK, et al. Longvida curcumin (400 mg/day) reduces rises in inflammatory and CK markers in a 4-day recovery model versus placebo (human study). Journal of Dietary Supplements. PubMed | PMC
  2. Nelson KM, et al. Curcumin formulation review: third-generation strategies (including SLCP/Longvida) improve systemic and free curcumin availability. Pharmaceutics. PMC
  3. Gota VS, et al. Longvida/SLCP human pharmacokinetics: free curcumin detectable in plasma; improved exposure versus conventional forms. Journal of Agricultural and Food Chemistry. PubMed

Astaxanthin and antioxidant defense

  1. Zhang L, et al. Astaxanthin meta-analysis (2022): reductions in oxidative-stress and inflammation biomarkers (human studies). Nutrients. PubMed
  2. Yuan JP, et al. Astaxanthin meta-analysis (2020): antioxidant effects versus control; trend toward lower MDA. Marine Drugs. PubMed

Spermidine and cellular longevity

  1. Kiechl S, et al. Spermidine intake and mortality in the Bruneck cohort: higher dietary intake associated with lower mortality over approximately 20 years. American Journal of Clinical Nutrition. PubMed
  2. Madeo F, et al. Spermidine and aging: review. Levels decline with age; exogenous spermidine reverses age-associated cellular changes (preclinical and early clinical evidence). Aging (Albany NY). PMC

Circadian rhythm and evening light exposure

  1. Chang AM, et al. Evening light-emitting eReaders suppress melatonin, delay circadian timing, and reduce next-morning alertness. Proceedings of the National Academy of Sciences (PNAS). PubMed | PNAS