When repair slows, aging accelerates - and you feel it.
RENEW works with your body’s night-time repair cycle. RENEW activates autophagy, balances inflammation, and protects your cells.
Recover while you sleep: Supports your body’s natural overnight repair
Wake up ready for the day ahead: Support the repair your body needs to perform
Support how your body ages: Helps your cells function better over time
Tomorrow starts tonight.
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Night is when your body does most of its repair. With age, repair slows, everyday inflammatory stress (“inflammaging”) rises, and natural spermidine production declines. Autophagy—your cells’ clean-up and recycle mode—can drift off schedule, so wear-and-tear lingers, next-day energy dips, and recovery lags.
RENEW takes a complete night approach: it supports autophagy/mitophagy, supports mitochondrial maintenance, and adds antioxidant defense to help lower everyday inflammatory stress—so night repair can finish and carry into tomorrow.
Sleep-friendly actives (behind the scenes):
• Longvida® Curcumin + EGCG help engage renewal pathways (autophagy/AMPK) and mitochondrial upkeep.
• Spermidine helps trigger and sustain cellular clean-up (autophagy/mitophagy).
• Astaxanthin adds membrane-focused antioxidant protection during the sleep window.
Simple night routine. No overthinking.
Clean-up → Recharge → Protect
Pair with VITALIZE: By day, VITALIZE supports NAD⁺/sirtuins for energy and daytime defense; at night, RENEW supports clean-up, mitochondrial maintenance, and night protection for a simple 24-hour rhythm.
Note: RENEW isn’t a sleep aid. It pairs well with magnesium (relaxation). Decaffeinated EGCG; not a stimulant.
How to take
Take 2 capsules in the evening with your main meal or ~60 minutes before bed.
Sensitive stomach? Take with food. Fasting? Take with your last meal. Aim for the same time each night.
Why night
Your body prioritizes repair during sleep. Taking RENEW at night aligns support for autophagy/mitophagy, mitochondrial maintenance, and antioxidant defense.
Lifestyle protocol (night routine)
• Evening meal: take RENEW; include protein for repair; hydrate for clearance.
• Wind-down: low light 1–2 h; screens off 30–60 min; avoid late alcohol—cues deeper sleep.
• Sleep window: consistent schedule; aim for 7+ hours for deeper repair.
Pairing
AM VITALIZE + PM RENEW = the essential cellular routine
Day: NAD⁺/sirtuins (energy, daytime defense)
Night: autophagy, mitochondrial maintenance, night antioxidant protection
Safety
RENEW isn’t a sleep aid. Magnesium can support relaxation; melatonin is a timing cue. You may take them with RENEW. If you use medication or have a condition, consult your clinician. (Decaffeinated EGCG.)
Allergens & suitability
Contains wheat (gluten) from wheat-germ extract (spermidine). Not suitable during pregnancy or breastfeeding.
Note
Do not exceed the recommended daily dose. Food supplements are not a substitute for a varied diet and healthy lifestyle. Keep out of reach of children. Store in a cool, dry place away from sunlight.
Clinically studied ingredients
Together they support night repair—clean up, recharge, protect—so you wake feeling more restored and support cellular renewal over time.
Why it works
Built for the sleep window: clean up, recharge, protect—so you wake ready and support cellular renewal over time.
What the evidence shows (by ingredient)
Human clinical work on bioavailable curcumin shows favorable shifts in inflammatory/oxidative-stress markers. Preclinical and early human research indicates spermidine and EGCG engage autophagy-linked pathways and mitochondrial quality control, while astaxanthin provides membrane-focused antioxidant defense. RENEW brings these threads together into a simple PM routine.
Pair with VITALIZE
AM VITALIZE + PM RENEW = a simple 24-hour cellular rhythm.
Day: NAD⁺/sirtuins for energy and daytime defense.
Night: autophagy, mitochondrial maintenance, PM protection (decaf EGCG).
Longvida® Optimized Curcumin® is the registered trademark of Verdure Sciences Inc. Patents: www.vs-corp.com/ip
Worldwide delivery
Typically 3-10 business days (varies by region). See Shipping Policy.
90-Day Guarantee
We’re confident you’ll feel the difference over time. If you’re not satisfied, email hello@cellaro.com within 90 days of delivery and we’ll refund one pouch from your first order - no return required.
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Made in Germany
Clinically studied ingredients
Third-Party Tested for Purity
What slows repair and drives aging
Cellular stress increases
Cells become more vulnerable to damage
Inflammation rises
Repair becomes less efficient
Damage accumulates
Repair processes work more slowly
Give your cells what they need overnight
A coordinated system that supports repair while you sleep.
Spermidine -c lears the damage
Removes damaged cellular components so repair can begin.
Curcumin - keeps the environment stable
Balances inflammation so repair can happen efficiently.
EGCG - reduces cellular stress
Helps maintain the conditions needed for repair.
Astaxanthin - protects during repair
Defends cells from oxidative stress while rebuilding takes place.
Repair signals activate
You may notice early shifts in sleep quality and recovery.
Start tracking trends in HRV.
Repair efficiency strengthens
As inflammation stabilizes, recovery becomes more consistent.
Consider retesting hs-CRP around 12 weeks.
Cellular stability builds
Look for longer-term trends in metabolic measurements like HbA1c and triglycerides.
Longevity Essentials
Energy. Repair. Repeat.
Your cells follow a daily rhythm
Daytime is for energy.
Night-time is for repair.
Longevity Essentials supports both.
VITALIZE (AM)
Replenishes NAD⁺ and supports cellular energy
RENEW (PM)
Supports repair, autophagy, and inflammation balance
Designed as a coordinated system.
Autophagy
Autophagy is the cell’s clean-up and recycling system.
Every day, normal activity creates cellular damage. Autophagy helps repair the damage by removing damaged components so cells can function and repair efficiently.
With age this process becomes less efficient, allowing damage to accumulate.
RENEW supports autophagy through spermidine, one of the most studied compounds linked to cellular recycling and repair.
Backed by research
Grounded in research on autophagy, cellular repair and inflammation biology.
Inflammation
Inflammation levels tend to rise with age and ongoing cellular stress.
When inflammation remains elevated, it can interfere with normal cellular maintenance and repair.
RENEW includes curcumin, EGCG and astaxanthin, compounds widely studied for their role in supporting balanced inflammatory responses.
Our Ingredients
Four compounds supporting overnight cellular repair.
Spermidine
Supports autophagy, the cellular maintenance process associated with healthy aging.
Explore
Longvida® Curcumin
Helps balance inflammation levels, creating favorable conditions for cellular repair.
Explore
EGCG
Polyphenol that helps protect cells and clear oxidative damage during overnight cellular renewal.
Explore
Cellaro RENEW is a nightly supplement designed to support cellular repair during sleep. It works with the body’s natural night-time repair window to support autophagy, mitochondrial maintenance, and antioxidant defence—helping recovery, resilience, and long-term cellular health.
No. RENEW is not a sleep supplement or sedative. It supports the biological repair processes that occur during sleep, without inducing drowsiness.
No. RENEW isn’t sedating and contains no stimulants. It uses decaffeinated green tea extract (EGCG); any residual caffeine is negligible. Most people report lighter mornings and steadier recovery, not drowsiness. If you’re sensitive to night supplements, take RENEW earlier in the evening or with a small snack.
Take RENEW in the evening, around the same time daily. With or without food is fine; if your stomach is sensitive, take with a small snack. Consistency matters more than the exact minute. For best results, keep late heavy meals and alcohol in check on weeknights.
Magnesium supports relaxation, and melatonin signals sleep timing. RENEW targets cellular night-time maintenance—autophagy, mitophagy, mitochondrial support, and antioxidant protection—so you wake with less physiological drag. It is not a sedative.
Yes. RENEW pairs well with magnesium; use any form/timing that suits you. Melatonin can be used occasionally (e.g., jet lag); keep doses modest. If you take prescription medicines or have a medical condition, check with your clinician before use.
Expect subtle shifts in weeks 2–4 (smoother recovery, easier mornings), with more consistent changes by 8–12 weeks. Responses vary by sleep, training, age, and stress. Daily use matters more than timing—keep your evening routine steady while you evaluate.
RENEW is for healthy adults. Do not use if pregnant or breastfeeding. If you take prescription medicines—especially anticoagulants—review the ingredient list with your clinician. Contains wheat-derived ingredients and gluten; avoid if you’re gluten-free or have a wheat allergy.
Look at weekly trends, not single nights. Useful signals: HRV, resting heart rate, awakenings, sleep efficiency/deep sleep, and your readiness/recovery score. Record a 7-day baseline (Week 0), check again at 4–8 weeks, and expect the clearest trend by ~3 months of consistent use.
Yes. Many people use VITALIZE (AM) for daytime cellular energy, RENEW (PM) for night-time repair, and RESET periodically as a short pulse. Each targets a different biological lever.
For skin support, RENEW can be taken alongside BOOST, which provides daily dermal nutrition. BOOST supports collagen quality, hydration, and barrier function during the day, while RENEW supports cellular clean-up and repair overnight. Follow each product’s label.
Longevity insights for cellular repair
[1] Ohsumi Y. Discovery of autophagy genes and the cellular recycling pathway. Nobel Prize in Physiology or Medicine, 2016. Press release | Advanced information
[2] Rubinsztein DC, et al. Autophagy and aging. Cell (Review). PubMed
[3] Ma D, et al. Circadian control of autophagy: clock genes regulate daily autophagy rhythms. Proceedings of the National Academy of Sciences (PNAS). PMC | PubMed
[4] Zhou J, et al. EGCG increases autophagosome formation and autophagic flux via AMPK involvement. Journal of Nutritional Biochemistry. PubMed | PMC
[5] McFarlin BK, et al. Longvida® curcumin (400 mg/day) reduces rises in inflammatory and CK markers in a 4-day recovery model versus placebo (human study). Journal of Dietary Supplements. PubMed | PMC
[6] Nelson KM, et al. Curcumin formulation review: third-generation strategies (including SLCP/Longvida®) improve systemic and free curcumin availability. Pharmaceutics. PMC
[7] Gota VS, et al. Longvida®/SLCP human pharmacokinetics: free curcumin detectable in plasma; improved exposure versus conventional forms. Journal of Agricultural and Food Chemistry. PubMed
[8] Zhang L, et al. Astaxanthin meta-analysis (2022): reductions in oxidative-stress and inflammation biomarkers (human studies). Nutrients. PubMed
[9] Yuan JP, et al. Astaxanthin meta-analysis (2020): antioxidant effects versus control; trend toward lower MDA. Marine Drugs. PubMed
[10] Kiechl S, et al. Spermidine intake and mortality in the Bruneck cohort: higher dietary intake associated with lower mortality over ~20 years. American Journal of Clinical Nutrition. PubMed
[11] Madeo F, et al. Spermidine and aging — review: levels decline with age; exogenous spermidine reverses age-associated cellular changes (preclinical and early clinical evidence). Aging (Albany NY). PMC
[12] Chang AM, et al. Evening light-emitting eReaders suppress melatonin, delay circadian timing, and reduce next-morning alertness. Proceedings of the National Academy of Sciences (PNAS). PubMed | PNAS