1-month daily routine + monthly RESET protocol
Microneedling triggers collagen repair signals in the dermis. BOOST and RESET are designed to maximize what your skin builds in the 12 weeks remodelling period that follows.
This protocol is designed to support that window - from the inside out.
BOOST builds and strengthens collagen structure through daily dermal support, reinforcing the matrix and maintaining hydration throughout recovery.
+39% elasticity · +44% firmness · +40% hydration · +26% luminosity
Independent clinical trial, 8 weeks
RESET clears and stabilizes by reducing senescence-related signals that can weaken collagen quality and accelerate structural breakdown during active remodelling.
Together, they protect your treatment investment — supporting firmness, matrix integrity, and consistent recovery between sessions.
Designed to integrate into professional treatment plans.
✦ Supports collagen synthesis during the 12-week remodelling phase
✦ Targets age-related senescent signalling linked to collagen degradation
✦ Promotes dermal matrix integrity during recovery
The DUO is designed to complement collagen stimulating treatments by supporting dermal rebuilding and controlling excess collagen breakdown during the 12 week remodelling phase.
Collagen stimulating treatments activate fibroblasts in the dermis. However, long term outcomes depend on the quality, organisation, and stability of the collagen that is rebuilt in the weeks that follow.
BOOST provides daily inside out dermal nutrition to support structured collagen formation, hydration, and matrix integrity throughout the remodelling window.
Collagen formation and structural support
Vitamin C and zinc contribute to normal collagen formation. SkinAx²® complex and REGGENERATE™ matrix fractions support dermal density, elasticity, and structural organisation.
Hydration and barrier stability
Oral hyaluronic acid and ceramides support moisture retention and skin comfort during recovery.
Oxidative balance and microcirculation support
Polyphenols, SOD, carotenoids, and astaxanthin help support balanced oxidative status and healthy dermal function.
During ageing and periods of active tissue turnover, senescent cells can accumulate in the dermis. These cells release inflammatory signalling factors that increase collagen degradation pressure and interfere with matrix quality.
RESET is a short, two day monthly pulse of complementary flavonoids including fisetin, quercetin (Quercefit®), and luteolin. The protocol is designed to help reduce excess senescent signalling while remaining supportive of normal cellular processes.
Why a pulse protocol?
Emerging senescence research supports periodic use rather than continuous daily dosing. This approach targets unwanted signalling while respecting healthy cellular function.
Together, BOOST and RESET help support collagen synthesis, matrix integrity, and visible firmness between treatment sessions, helping clinics optimise long term patient outcomes across a treatment series.
BOOST (daily AM)
Take 2 capsules every morning, with or without food.
Many people take BOOST alongside their morning skincare to build a consistent routine.
RESET (monthly)
Once per month, take 4 capsules per day for 2 consecutive days. (2 in the morning, 2 in the evening).
Avoid RESET within ±5 days of in-office aesthetic treatments.
Good to know
• Stay well hydrated on RESET days
• Avoid alcohol during the pulse
• BOOST contains egg (REGGENERATE™)
General
Adults only. If pregnant, nursing, or taking prescription medication, consult your clinician.
Why these two together
BOOST supplies daily nutrition that supports collagen, elasticity, hydration, and antioxidant defense. RESET helps clear monthly cellular roadblocks linked to collagen breakdown, so results build over time.
BOOST — Daily AM
Serving size (per day): 2 capsules
REGGENERATE™ Eggshell Membrane — 300 mg
Supports elasticity and barrier function (TEWL reduction reported in human data). Allergen: egg.
SkinAx²™ Lift — 200 mg
Polyphenol-rich grape & melon complex to support radiance, texture, and collagen defense against everyday oxidative stress.
Hyaluronic Acid (≈80 kDa) — 120 mg
Helps bind water within the skin for sustained hydration and improved elasticity over time.
Ceramides — 30 mg
Replenishes skin lipids to strengthen the surface barrier and reduce transepidermal water loss (TEWL).
Astaxanthin — 6 mg
Carotenoid antioxidant supporting the skin’s antioxidant defenses against daily stressors.
Vitamin C — 80 mg
Collagen co-factor; contributes to normal collagen formation and protection of cells from oxidative stress.
Why it lasts
Working in the viable epidermis and dermis, BOOST supports renewal cycles, ongoing collagen maintenance, hydration dynamics, and barrier performance—so improvements accumulate with daily use and complement surface care.
Trademarks: SkinAx²™ is a registered trademark of ACTIV’INSIDE. REGGENERATE™ is a registered trademark of Circul’Egg.
See Science page → BOOST references.
RESET — Monthly 2-day pulse
Serving size (per pulse day): 4 capsules (2 AM + 2 PM)
Fisetin— 1,000 mg
Designed to support the body’s natural clearance of aging (senescent) cells and ease background cellular stress.
Quercetin (Quercefit® phytosome) — 500 mg
Complements fisetin across senescence-related pathways; phytosome form improves absorption vs standard quercetin.
Luteolin — 125 mg
Supports balanced inflammatory signaling and antioxidant defenses; known to cross the blood–brain barrier.
Black Pepper Extract — 25 mg
Included at a low dose to support polyphenol uptake during the 2-day pulse.
Why three flavonoids?
Broader pathway coverage in a short, high-impact cadence—aimed at what’s old while remaining healthy-cell-friendly.
Trademark: Quercefit® is a registered trademark of Indena S.p.A.
Shipping
Worldwide delivery — 3–10 business days from dispatch (varies by region). See Shipping & Returns.
90 Day Guarantee
We’re confident you’ll feel the difference. Results build over 2–3 months. If you’re not satisfied, email support@cellaro.com within 90 days of delivery and we’ll refund one pouch from your first order — no return required.
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Skin Aging Begins at the Cellular Level
Collagen strength depends on what happens inside the dermis.
Topical products act mainly at the surface. Collagen rebuilding happens deeper in the dermis and requires support from within.
BOOST builds and strengthens dermal structure through daily support for collagen formation and hydration.
RESET clears and stabilizes by helping reduce senescence-related signals that can interfere with collagen during active remodeling.
A coordinated daily and monthly approach designed to support dermal remodeling across a treatment cycle.
Collagen renewal over time
Daily BOOST supplies dermal nutrients that support collagen and elastic-fiber renewal, while monthly RESET helps clear lingering senescent cells that disrupt skin structure.
Together, they drive deeper skin renewal, a stronger collagen network, better hydration, and smoother texture over time. When combined with aesthetic treatments such as microneedling or laser, DUO helps optimise the internal environment where visible results are built.
Our Ingredients
Clinically studied ingredients, built for inside-out skin renewal and lasting radiance.
Reggenerate™
Eggshell-derived collagen to boost elasticity, hydrate deeply, and promote glowing, resilient skin from the inside out.
Explore
SkinAx²™
Clinically proven matrix that forms the structural core of BOOST — promoting firmer, smoother, more hydrated skin from within.
Explore
Fisetin
RESET’s foundation senolytic — clinically studied to target senescent cells and support full-body cellular renewal.
Explore
Quercetin
Quercefit® quercetin (phytosome) — higher absorption. Works alongside fisetin on inflammatory and oxidative pathways.
ExploreDUO is an inside-out skin longevity system combining daily dermal nutrition (BOOST) with a monthly 2-day senescence reset (RESET). It supports collagen quality, hydration, and elasticity daily while periodically reducing age-related cellular signals linked to collagen breakdown.
DUO pairs BOOST (daily) and RESET (monthly) to support skin structure from within, while topical skincare works at the surface. BOOST supplies dermal nutrition for collagen quality, hydration, and barrier lipids. RESET is a senescence-focused monthly protocol that helps dial down background stress signals linked to dullness and collagen breakdown pressure. Use DUO with a simple topical routine for best results.
Topicals mainly act in the epidermis (surface barrier; faster turnover ~4–6 weeks). DUO supports the dermis—the collagen/elasticity/hyaluronan matrix that drives firmness and texture—while also benefiting the viable epidermis. Inside + outside = complementary effects. Inside + outside = complementary effects at different skin depths.
Take BOOST: 2 capsules each morning with water.RESET: take 4 capsules/day for 2 days in a row, once per month (e.g., Days 1–2). Follow the label instructions.
BOOST is taken daily, year-round. RESET is taken once per month for two consecutive days.
Duo combines daily build (BOOST) with a short monthly reset (RESET) focused on senescence. Glow & Repair is a day/night system (BOOST + RENEW) centered on daily defense and nightly autophagy-linked repair.
Choose DUO if your goal is to support collagen structure and reduce age-related breakdown signals over time — with the added benefit of helping optimise the skin environment before and after aesthetic treatments.
Choose Glow & Repair if your focus is daily skin biology — amplifying skincare by supporting hydration, barrier repair, and night-time renewal.
Senescent (“aging”) cells accumulate with age and release SASP—signals that raise background inflammatory/oxidative stress. This increases collagen-breaking pressure, contributing to dullness, laxity, and slower recovery. Duo targets both sides: build quality daily (BOOST) and periodically temper that background noise (RESET).
Senescence biology is being explored with brief, intermittent pulses rather than continuous dosing. Duo follows that emerging approach: a short 2-day protocol to target background signals while staying friendly to healthy cells.
This approach reflects how senescence-targeting compounds are typically studied: intermittent, not continuous.
Topicals work mainly at the epidermis (surface barrier). Duo supports from within—reaching the dermis, where collagen/elastic/HA networks shape firmness, texture, and resilience. Inside + outside are complementary.
UV/blue light, pollution, oxidative stress, glycation (high sugar), and stress/sleep debt. These raise collagen breakdown pressure and deplete antioxidant capacity. BOOST supports collagen conditions, hydration, and antioxidant defense each day.
Inside-out first, then topicals. AM: take BOOST, then vitamin-C/antioxidant serum → moisturizer → SPF. Monthly: run the 2-day RESET on schedule. Keep sunscreen daily.
Hydration/feel can improve in 2–4 weeks. Texture, elasticity, and firmness signals generally build over 6–12+ weeks, especially as you run the monthly reset consistently.
Results vary by age, baseline skin health, and consistency.
People seeing early signs of dullness, uneven tone, slower bounce-back, or higher lifetime exposure (sun, urban pollution, intense training) who want daily support plus a periodic clean-up.
Longevity insights for skin health
[1] Oral hyaluronic acid (120 mg/day; 8–12 weeks). Improvements in skin hydration and elasticity; fine lines appear softer. PubMed
[2] Oral ceramides (~60–90 days). Increases in hydration and elasticity; reductions in TEWL and roughness (human). PubMed
[3] Eggshell membrane (~300–450 mg/day; ~8 weeks). TEWL decreases; elasticity and appearance improve (human). PubMed
[4] SkinAx² (8 weeks; dermatological control). Wrinkle depth ↓ ~11%; luminosity ↑ ~26–29%. PubMed
[5] Astaxanthin (oral; 2022 meta-analysis). Improved oxidative/redox markers; supportive skin findings. PubMed
[6] Vitamin C in skin biology. Collagen cofactor; antioxidant and photoprotective roles (review). PMC
[7] Cellular senescence overview. Mechanisms and SASP concept. PubMed
[8] Inflammaging. Age-related low-grade chronic inflammation. PubMed
[9] First human senescence-targeted pilot (intermittent D+Q). Improved 6-minute walk distance. PubMed
[10] Senolytics review and dosing rationale. Discovery → translation; intermittent pulse dosing. Wiley
[11] Eggshell membrane (REGGENERATE™). Randomized, double-blind, placebo-controlled human RCT; 300 mg/day, 60 days: skin firmness +51%, elasticity +25%, TEWL ↓ (supportive). (Add supplier white paper / publication details.) Supplier
Skin Renewal Duo
From 1,088 kr/month · 90-day guarantee