Includes VITALIZE (AM) and RENEW (PM). 1-month supply.
A foundational AM–PM routine designed to work with your body’s natural cycles, supporting cellular energy by day and repair by night. Informed by longevity science and built for daily consistency.
24-hour circadian support for energy and repair
AM: daily cellular fuel for steady daytime energy.
PM: nightly cellular repair for recovery and resilience.
Foundation for long-term cellular health and healthy aging.
As we get older, two things quietly shift: daytime energy takes more effort and night-time repair gets less efficient. NAD⁺ levels decline, repair processes slow, and low-grade inflammatory stress creeps up—so days feel heavier and recovery lags.
Longevity Essentials is your simple, daily way to support those foundations. By day, VITALIZE focuses on the NAD⁺ cycle—helping rebuild, preserve, and recycle this key cofactor so cells have the “battery” they need for steadier energy, clearer focus, and better bounce-back. At night, RENEW backs cellular clean-up (autophagy/mitophagy), mitochondrial maintenance, and antioxidant defense, aligned with your sleep window so repair can actually finish.
Together, AM VITALIZE and PM RENEW create a coordinated 24-hour rhythm for your cells: charge the system when you’re awake, clear and repair when you sleep.
How to take
Morning — VITALIZE
Take 2 capsules each morning, with or without food.
If fasting, take with your first meal. Aim for the same time every day.
Evening — RENEW
Take 2 capsules in the evening with your main meal or about 60 minutes before bed.
Sensitive stomach or fasting? Take with your last meal.
Why this routine
Day is when cells spend the most energy; night is when most repair happens.
Morning VITALIZE supports the NAD⁺ cycle and daytime defenses ahead of demand.
Night-time RENEW aligns autophagy, mitochondrial maintenance, and antioxidant defense with your sleep window so repair can finish.
Lifestyle protocol (24-hour rhythm)
AM:
Hydrate before coffee; light movement or a short walk; take VITALIZE with a protein-containing meal
PM:
Take RENEW with dinner; keep late alcohol modest; dim lights and reduce screens 30–60 minutes before bed; aim for a consistent 7+ hour sleep window.
Safety & allergens
Contains wheat (gluten) via RENEW (wheat germ extract); not suitable for coeliac disease, gluten intolerance, or wheat allergy. Food supplements are not a substitute for a varied diet. If you are pregnant, breastfeeding, taking medication, or have a medical condition, consult your doctor before use and follow the individual product labels.
Clinically studied ingredients
Together they support 24-hour cellular health—AM energy, PM repair.
Day — VITALIZE (AM cellular energy)
Uthever® NMN – Build NAD⁺
Direct NAD⁺ precursor to support cellular energy and repair.
Trans-Resveratrol – Activate sirtuins
Polyphenol that supports NAD⁺-dependent sirtuins and stress resilience.
Apigenin (ApiAge™) – Preserve NAD⁺
Helps counter excessive CD38 activity, supporting NAD⁺ economy with age.
Trans-Pterostilbene – Protect
Highly bioavailable stilbene supporting antioxidant and metabolic signalling.
Trimethylglycine (TMG) – Methylation support
Provides methyl groups for homocysteine metabolism and NAD⁺ recycling.
Black Pepper Extract – Uptake support
Low-dose piperine to support polyphenol absorption.
Night — RENEW (PM repair & resilience)
Spermidine – Clean up & renew
Wheat-germ extract (contains wheat/gluten) supporting autophagy/mitophagy.
Longvida® Optimized Curcumin® – Inflammation & defense
Supports balanced inflammatory responses and night-time antioxidant protection.
Green Tea Extract (EGCG) – Reinforce
Decaffeinated EGCG to support renewal pathways and cellular protection.
Astaxanthin – Membrane protection
Carotenoid helping shield mitochondria and cell membranes from oxidative stress.
Shipping
Worldwide delivery — 3–10 business days from dispatch (varies by region). See Shipping & Returns.
90 Day Guarantee
We’re confident you’ll feel the difference. Results build over 2–3 months. If you’re not satisfied, email support@cellaro.com within 90 days of delivery and we’ll refund one pouch from your first order — no return required.
Choose options
Made in Germany
Clinically studied ingredients
Third-Party Tested for Purity
Optimized Multi-Active Formulas
How Longevity Essentials fits your day
Two capsules in the morning, two at night — one simple base for energy and repair.
Day and night form a cellular loop
Day — energy and load
During the day, cells prioritise energy and performance: producing ATP, supporting focus, movement, and stress response. When NAD⁺ and cellular fuel are low, efficiency drops and oxidative stress rises.
Night — repair and reset
At night, biology shifts to clean-up and repair: autophagy, damage control, and calming inflammation. This repair requires both time and fuel (including NAD⁺ and repair nutrients like spermidine).
The loop
Low energy by day and incomplete repair at night reinforce each other. Short term, this feels like heavier days and slower recovery. Over time, it accelerates cellular aging.
NAD⁺ powers both sides of the 24-hour cycle
NAD⁺ is a small co-factor your cells use everywhere: to make ATP during the day and to run key repair and clean-up processes at night. It’s one shared NAD⁺ reserve for both energy and maintenance, not separate tanks.
From your 30s, NAD⁺ levels tend to fall; by midlife they can be roughly 50% lower than in youth. With a smaller reserve, your cells have less flexibility — more trade-offs between getting you through the day and completing deeper repair at night. Over time, that underfunded repair quietly adds to cellular strain.
Longevity Essentials is designed to support this shared NAD⁺ reserve across the 24-hour cycle, with a dedicated formula for morning energy and another for night-time repair.
Our Ingredients
Uthever® NMN
Directly boosts NAD⁺ levels, the essential building block for cellular energy and repair. Clinically studied, >99% pure.
Explore
Trans-Resveratrol
Activates NAD⁺-dependent sirloins and supports AMPK signaling for efficient energy use and stress resilience.
Explore
Longvida® Curcumin
Sustained anti-inflammatory action — helps create an optimal overnight environment for autophagy, repair, and mitochondrial renewal.
Explore
Spermidine
Drives autophagy — your body’s natural process of clearing and renewing damaged cells — promoting long-term cellular resilience.
Explore
First signs
Energy more even
Lighter mornings
Energy & repair strengthen
Stamina lasts longer
Recovery feels easier
Compounded cellular support
Improved daily vitality
Enhanced cellular function
Complete your routine
Adding RESET provides a monthly cellular reset — a focused 2-day senolytic pulse that helps clear dysfunctional cells and create space for healthier cellular renewal alongside your daily routine.
Senescence: helps clear lingering senescent cells
Inflammation: supports age-related inflammatory balance
Maintenance: deepens long-term cellular maintenance
Together, Longevity Essentials + RESET form Longevity Core, extending support across all 12 hallmarks in our framework.
Longevity Insights
Longevity Essentials is your foundational AM/PM cellular routine, aligned with your natural day–night rhythm.VITALIZE works in the morning to support daytime energy, focus, and vitality.RENEW works at night to support cellular repair, inflammation balance, and antioxidant protection. Together they help stabilise a 24-hour cycle: energy by day, repair at night.
Your cells do not do the same work all day. Daytime is biased towards energy production, performance, and handling stress. Night-time leans towards repair, autophagy, and damage control.
Splitting the routine into an AM and a PM formula lets you give different inputs at the right window: more NAD⁺ and daytime support in the morning, more repair-focused actives in the evening. It also keeps pill load lower at any one time and makes the routine easier to stick with.
VITALIZE: Take two capsules in the morning with water or coffee, with or without food. If your stomach is sensitive, take it with a light breakfast or snack.
RENEW: Take two capsules in the evening with your evening meal or shortly before bed. Aim for roughly the same time each night.
If you miss a dose, simply resume at the next AM or PM; there is no need to double up.
Many people notice early shifts in weeks 2–4, such as more even daytime energy and lighter mornings. By 8–12 weeks, patterns are usually clearer: stamina lasts longer, recovery feels easier, and daily vitality is more stable. Sleep quality, training load, and stress will influence how quickly you notice changes.
If you use a wearable, it can be helpful to watch weekly trends in HRV, resting heart rate, sleep efficiency or deep sleep, and recovery or readiness scores over 4–12 weeks. Some people also track NAD⁺ with a baseline and follow-up blood test, as outlined on the Science page, but that is optional.
No. This is not a drug that stops aging. Longevity Essentials is designed to support healthspan by improving cellular processes that are linked to the Hallmarks of Aging, such as NAD⁺ decline, increased oxidative stress, and low-grade inflammation.
The AM formula focuses on NAD⁺-related energy pathways and daytime resilience; the PM formula focuses on night-time repair, autophagy, mitochondrial upkeep, and antioxidant defences. Together, and alongside sleep, nutrition, movement, sun protection, and stress management, the goal is healthier, more resilient cells over time—not a promise to freeze aging.
Yes. Longevity Essentials is meant to be your daily base.
RESET can be added once per month as a focused two-day senolytic pulse for deeper cellular renewal.
BOOST can be taken in the morning with food when you want extra support for skin, collagen, hydration, and visible radiance.
Keep the routine simple and follow the instructions on each label.
The routine is intended for healthy adults and uses high-purity, third-party-tested ingredients at clinically aligned doses.Do not use if you are pregnant or breastfeeding.If you take prescription medicines, especially those affecting blood clotting, immunity, or liver function, or if you have a medical condition, review the ingredient lists with your clinician before starting.RENEW contains wheat-derived ingredients and is not suitable for people who avoid gluten or have wheat allergies.
NAD⁺, energy, and aging
[1] Imai S-I, Guarente L. NAD⁺ and sirtuins in aging and disease. Trends in Cell Biology. 2014;24(8):464–471. [2] Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, dose-dependent trial. Geroscience. 2023;45(1):29–43. [3] Huang H. A multicentre, randomised, double-blind, parallel-design, placebo-controlled study to evaluate the efficacy and safety of Uthever® (NMN supplement) in middle-aged and older adults. Frontiers in Aging. 2022;3:851698.
Night-time repair, autophagy, and inflammation
[4] Rubinsztein DC, et al. Autophagy and aging. Cell. (Review). [5] McFarlin BK, et al. Longvida® curcumin (400 mg/day) reduces rises in inflammatory and CK markers in a 4-day recovery model versus placebo (human study). Journal of Dietary Supplements. [6] Madeo F, et al. Spermidine and aging — levels decline with age; exogenous spermidine reverses age-associated cellular changes (preclinical and early clinical evidence). Aging (Albany NY). [7] Kiechl S, et al. Spermidine intake and mortality in the Bruneck cohort: higher dietary intake associated with lower mortality over ~20 years. American Journal of Clinical Nutrition. [8] Zhang L, et al. Astaxanthin meta-analysis (2022): reductions in oxidative-stress and inflammation biomarkers in human studies. Nutrients.
