A well-studied NAD⁺ precursor for steady daytime cellular maintenance.
Hallmarks supported: Epigenetic Alterations · Mitochondrial Function · DNA Damage Response
What is NMN?
Nicotinamide mononucleotide (NMN) is a vitamin B3–derived molecule that your body naturally produces and uses to make NAD⁺, a coenzyme central to cellular energy metabolism, sirtuin signaling, and DNA repair. NMN feeds the NAD⁺ salvage pathway, helping replenish NAD⁺ levels that gradually decline with age.
This age-related decline in NAD⁺ is associated with less efficient cellular energy production and maintenance processes, which is why NMN has been studied as a way to support the body’s existing NAD⁺ biology rather than introduce a foreign compound.
Why β-NMN matters
Only the β-isomer of NMN is biologically active in the NAD⁺ salvage pathway. Uthever NMN is specified and verified as 100% β-NMN, ensuring the form used in human research and cellular metabolism.
How NMN supports NAD⁺ and energy
As NAD⁺ gradually declines with age, the systems that rely on it, including mitochondrial output, sirtuin activity, and DNA repair enzymes, work less efficiently. NMN is converted to NAD⁺ inside cells, helping replenish this pool so daytime cellular maintenance runs smoothly, supporting mitochondrial function, sirtuin signaling, and DNA upkeep.
Quality and stability standards
Identity and purity
We use Uthever β-NMN, authenticated by NMR and LC-MS as 100% β-isomer and specified at ~99%+ purity. This confirms the active configuration and tight impurity control specified for human research–grade material.
Stability over time
Uthever’s longitudinal data at 25 °C/60% RH show high purity with low moisture gain through 24 months when packaged correctly (double-layer PE bags, fiber drums). Translation: consistent material over shelf life.
Human evidence (people-tested)
A 60-day, randomized, placebo-controlled study of Uthever NMN (300 mg/day) reported higher circulating NAD⁺/NADH and favorable trends in functional readouts (6-minute walk, SF-36). Safety labs remained in normal ranges.
Pathways and outcomes studied
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Increased circulating NAD⁺/NADH in a randomized, placebo-controlled human trial (Uthever NMN, 300 mg/day, 60 days).
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Functional readouts assessed in the same study included walking distance (6-minute walk) and quality-of-life measures (SF-36).
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Broad mechanistic literature links NAD⁺ availability to mitochondrial function, sirtuin activity, and DNA maintenance pathways.
How NMN fits into a daily routine
In daily longevity routines, NMN is commonly used in the morning to support the NAD⁺ pool that fuels cellular energy, sirtuin activity, and repair enzymes. It is often paired with complementary compounds such as polyphenols like resveratrol and pterostilbene, which engage overlapping maintenance pathways, and nutrients such as trimethylglycine (TMG), which supports methyl balance, creating a more complete approach to daytime cellular efficiency.
Dosage context
What VITALIZE provides: 500 mg β-NMN (Uthever) per day.
Why 500 mg: Chosen to deliver clear, day-to-day NAD⁺ support within commonly studied human ranges. It’s designed for impact as a simple two-capsule daily routine.
What research uses: Most human studies use 250–600 mg/day and report good tolerability.
What this means for you: Use the label amount as your steady daily routine. If you later choose to personalize with your clinician (for example, shifting toward 1 capsule/ 250 mg/day), do so based on your goals, labs, or budget. Always follow label directions.
NMN from food vs supplements
NMN occurs in small, variable amounts in foods; a standardized serving provides predictable daily support without relying on diet variability.
Research snapshot
People-tested NAD⁺ increase
A 60-day randomized, placebo-controlled trial of Uthever NMN showed higher NAD⁺/NADH versus placebo, with supportive trends in functional readouts such as the 6-minute walk and SF-36.. Source: Huang et al., Frontiers in Aging (2022)
Read the full clinical evidence →
Quality you can verify
β-isomer identity confirmed by NMR and LC-MS; ~99%+ purity; stability documented to 24 months at 25 °C/60% RH in validated packaging; global certifications and active EU Novel Food submissions.
FAQs
Is NMN the same as NR?
NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are both vitamin B3–derived compounds used by the body to produce NAD⁺. They follow slightly different biochemical steps before entering the same NAD⁺ salvage pathway. Human research exists for both, and neither has been shown to be universally “better” for everyone.
When should I take NMN?
NMN is commonly taken in the morning, as NAD⁺ supports daytime cellular energy and metabolic activity. Morning use also aligns with circadian biology, as many NAD⁺-dependent processes are more active earlier in the day. Always follow the product label and guidance from your healthcare professional.