A standardized wheat-germ–derived source of spermidine that supports the body’s natural cleanup and renewal processes during sleep.
Hallmarks supported: Proteostasis/Autophagy · Mitochondrial Function · Inflammatory Signaling
What is spermidine?
Spermidine is a naturally occurring polyamine found in human cells and in foods such as wheat germ, soy, and certain mushrooms. Inside the body, it plays a role in cellular housekeeping processes, most notably autophagy, the mechanism by which cells clear damaged components and recycle materials for renewal.
In Cellaro, spermidine is provided as a standardized wheat germ extract, delivering a predictable, low-milligram amount suitable for consistent evening use as part of a structured PM routine.
How spermidine supports cellular processes
As we age, cellular cleanup pathways become less efficient and damaged components can accumulate. Spermidine has been studied for its ability to support autophagy and related quality-control mechanisms, helping cells recycle worn-out parts and maintain functional integrity.
By supporting these housekeeping processes, spermidine contributes to:
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ongoing cellular renewal,
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mitochondrial quality control, and
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a calmer baseline for inflammatory signaling.
This makes spermidine particularly well aligned with overnight repair and recovery, when the body naturally prioritizes maintenance and renewal.
Pathways and outcomes studied
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Supports autophagy and cellular cleanup pathways
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Supports mitochondrial quality control and resilience
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Contributes to balanced inflammatory signaling as part of recovery processes
How spermidine fits into a daily longevity system
In the Cellaro system, spermidine is not intended as a standalone supplement. It is included in RENEW, the evening formula designed to support overnight cellular repair.
Spermidine complements:
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Longvida® Curcumin, which supports inflammatory balance and recovery signaling, and
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EGCG and astaxanthin, which contribute antioxidant and mitochondrial support.
Together, these ingredients help create a supportive environment for night-time cellular maintenance, without stimulation, aligning with the body’s natural repair rhythms during sleep.
Dosage context
What RENEW provides
400 mg wheat germ extract per evening (providing 4 mg spermidine) per 2-capsule serving.
What research uses
Human supplementation studies commonly use approximately 1–6 mg/day of spermidine from wheat germ extract. Many interventions fall in the 1–3 mg/day range, with safety signals reported up to ~6 mg/day. Observational studies associate higher dietary spermidine intake with markers of healthy aging.
What this means for you
A nightly dose providing 4 mg spermidine is selected to support overnight cellular renewal as part of a PM repair routine alongside curcumin, EGCG, and astaxanthin. Take in the evening as directed on the label.
Research snapshot
Autophagy and cellular housekeeping
Spermidine is a physiological inducer of autophagy and has been studied for its role in cellular cleanup and renewal across experimental models.
Healthy aging signals
Population studies associate higher dietary spermidine intake with lower all-cause and cardiovascular mortality. Randomized trials in older adults are ongoing to further explore these associations.
FAQs
Does this ingredient contain gluten?
Yes. Because the source is wheat germ, this ingredient contains gluten. If you have celiac disease or gluten sensitivity, consult your clinician and consider a gluten-free alternative.
How is spermidine obtained from wheat germ?
Wheat germ is milled and extracted, then purified and standardized to deliver a defined low-milligram amount of spermidine per serving. Due to its wheat origin, the final ingredient is not gluten-free.
Is this the same as eating wheat germ?
No. Whole wheat germ contains variable amounts of spermidine along with gluten and other compounds. The ingredient used here is a standardized extract that provides consistent spermidine dosing per capsule, while still containing gluten due to its source.