Two things are usually working against basic NAD+ supplements. First, CD38, an enzyme that increases with age, actively consumes NAD+ as fast as you build it. If you are not inhibiting CD38, you are filling a bucket with a hole in it. Second, most formulas have no recycling support. Around 80% of the NAD+ your body uses is recycled through the salvage pathway, not made from scratch. Without TMG to keep that cycle running, levels rise briefly and then fall back down. And without methyl group replenishment, sustained NAD+ supplementation can actually leave you feeling more tired over time.

VITALIZE addresses all of this. Apigenin (ApiAge™) inhibits CD38 to slow the drain. TMG supports the recycling pathway and keeps your methylation reserves balanced. If you tried another product and the effect was weak or wore off quickly, this is likely why.

Both are precursors to NAD+, but NMN is one step closer. NR must first convert to NMN before it can become NAD+, which adds a conversion step and potential for loss. Uthever® NMN, the form used in VITALIZE, is 99% pharmaceutical-grade pure and is the only NMN with human clinical studies directly measuring blood NAD+ increases. Most NR products do not have equivalent clinical validation at the ingredient level.

CD38 is an enzyme your immune cells use to signal inflammation. The problem is that its activity increases significantly with age, and it consumes NAD+ as a byproduct. Research suggests that rising CD38 activity is one of the primary reasons NAD+ levels drop as we get older. It is not just that we produce less. Something is actively breaking it down faster.

Apigenin (ApiAge™) is a natural CD38 inhibitor. By slowing CD38, it reduces how quickly your NAD+ is consumed, which means the NAD+ you build with NMN stays in circulation longer. ApiAge™ is a patented, standardized form, which matters because potency in unbranded apigenin varies widely.

They are directly connected. Resveratrol and Pterostilbene activate sirtuin enzymes, the longevity proteins that use NAD+ as fuel. Without activation, you can have elevated NAD+ but it does not automatically get directed toward cellular energy and repair. The activation step is what ensures your NAD+ is being put to work.

Pterostilbene is included alongside Resveratrol because it has superior bioavailability and a longer half-life in the bloodstream, making the combined effect more sustained than Resveratrol alone.

Most customers notice something within the first one to two weeks: more consistent energy, fewer afternoon drops, and cleaner mental clarity in the morning. The effect becomes more pronounced around the four-week mark as NAD+ levels build.

In our independent testing, blood NAD+ levels increased by 51% to 128% after 30 days depending on age. Older individuals tend to start lower and see a larger relative increase. For meaningful cellular-level changes, most longevity researchers recommend a consistent three-month minimum.

When NMN is metabolized into NAD+ and then broken down, the process consumes methyl groups from your body's methylation reserves. Over time, supplementing NMN without replacing these methyl groups can deplete your methylation capacity, which can cause fatigue and reduce the effectiveness of the supplement itself.

TMG (trimethylglycine) donates methyl groups to keep the cycle balanced. It also directly supports the salvage pathway, the recycling loop that handles 80% of your body's NAD+ turnover. Without TMG, that depletion compounds over weeks and can leave you feeling more tired than when you started. Products without TMG are leaving this gap open.

VITALIZE is formulated as a complete AM formula and pairs well with RENEW (the PM formula in the Cellaro system, which supports autophagy and overnight cellular repair). For most people, there is no need to add standalone NMN, NR, or Resveratrol on top. They are already included at effective doses.

If you take prescription medications or have a specific health condition, consult your doctor before starting any new supplement routine.

500 mg is the dose used in the Uthever® clinical research showing measurable blood NAD+ increases. It is the most validated starting point. Two capsules per day covers this.

After 4 to 8 weeks, the best way to personalise is to test your NAD+ levels. Some people, particularly those who are active or over 40, find they get the most from staying at 500 mg. Others test lower and maintain at 250 mg (1 capsule). If you are new to NAD+ supplementation, starting at 1 capsule for the first one to two weeks before moving to 2 is a reasonable way to let your body adjust. Consistency matters more than the exact dose. The data shows cumulative gains over months, not days.

IV drips bypass the gut and deliver NAD+ directly to the bloodstream, which creates an immediate spike. The problem is that NAD+ has a short half-life and is metabolized quickly. The spike falls. And just like basic supplements, IV drips do not address CD38 or support the recycling pathway, so the same fundamental gaps remain.

VITALIZE works differently: it gives your cells the precursors and the protection to build and sustain their own NAD+ daily. It fits real life, does not require a clinic visit, and costs a fraction of what regular IV sessions run.

If you are considering both: measure, do not guess. A blood NAD+ test before and after either approach will tell you what is actually happening.

Take 2 capsules every morning, ideally at the same time each day. Taking with breakfast is the simplest approach. If you fast in the mornings, take VITALIZE with your first meal. A small amount of dietary fat can support absorption of the fat-soluble polyphenols (Resveratrol and Pterostilbene), so taking it alongside food rather than on an empty stomach is preferred but not required.

Coffee is fine. There is no known interaction. Training days and rest days are both VITALIZE days: the cellular benefits are cumulative and build with consistency, not intensity.