NAD⁺ levels decline with age, affecting mitochondrial energy production, DNA repair, and sirtuin signaling. At the same time, NAD⁺ follows a natural circadian rhythm, with production highest during the daytime. Supporting NAD⁺ in alignment with this rhythm helps reinforce its role in daily cellular energy and repair processes.

Rebuilding NAD⁺ starts with supplying the right precursor. NMN sits one enzymatic step from NAD⁺, making it more direct than NR, which requires an additional conversion step first. Clinical trials using Uthever® NMN show circulating NAD⁺ rising by 38% at 60 days versus 14% in placebo, with improved physical function, stable insulin sensitivity, and good tolerability across multiple RCTs. Daily use supports steady, measurable replenishment of the cellular NAD⁺ pool.

Building NAD⁺ is only part of the equation. With age, CD38 activity increases and accelerates NAD⁺ breakdown faster than supplementation alone can replace it. ApiAge™, a patented standardized apigenin extract with enhanced bioavailability, inhibits CD38 directly, protecting the NAD⁺ reserve you build and supporting mitochondrial efficiency over time. Generic apigenin is poorly absorbed and unstandardized; the CD38 inhibition data in the literature was generated with standardized preparations, which is why form matters here.

NAD⁺ fuels the system, but signaling determines the outcome. Elevated NAD⁺ is the input; sirtuins, particularly SIRT1, are the enzymes that use it to execute cellular repair, regulate metabolism, and protect DNA. Without sirtuin activation, higher NAD⁺ levels do not translate proportionally into cellular output. Resveratrol is a direct SIRT1 activator. Pterostilbene is a structural analog with higher bioavailability, better blood-brain barrier penetration, and a longer half-life. Both are included because they operate on the same target through slightly different kinetics, supporting SIRT1 and AMPK pathways and helping translate NAD⁺ availability into functional cellular outcomes.

NAD⁺ fuels the system, but signaling determines the outcome. Polyphenols such as resveratrol, pterostilbene, and apigenin support sirtuin and AMPK pathways, helping translate NAD⁺ availability into functional cellular effects.

Effective NAD⁺ support depends on quality and stability. Ingredient identity, purity, and real-world tolerability matter. VITALIZE is built around Uthever® NMN, the only NMN ingredient to have received a positive EFSA scientific opinion (May 2026), confirming safety and bioavailability under EU Novel Food review. It is the only NMN backed by a published human RCT that directly measured blood NAD⁺ before and after supplementation, and it carries ≥99% pharmaceutical-grade purity verified independently per batch. Every ingredient in VITALIZE is in a clinically studied form, at a meaningful dose, designed for consistency and long-term use.

Autophagy is the core cellular renewal pathway that runs primarily during sleep. It clears damaged proteins and mitochondria, supports energy efficiency, and helps maintain balanced inflammatory signaling. Age-related decline in autophagy is linked to reduced resilience and healthspan.

Spermidine activates autophagy, the cell’s internal renewal program. Experimental models show lifespan extension requires autophagy activation, and human data link higher intake to markers of healthy aging and preserved function.

Curcumin is a well-studied polyphenol that modulates inflammatory and cellular repair pathways. Longvida® technology enhances systemic exposure, enabling meaningful biological activity at clinically relevant doses.

EGCG activates AMPK-linked signaling pathways that help coordinate cellular repair and energy balance. Clinical research associates green tea catechins with improvements in inflammatory and metabolic markers.

Astaxanthin is a membrane-targeting antioxidant that helps protect cells from oxidative stress. Human studies suggest it can support healthier inflammatory and oxidative stress markers, making it a useful complement to nightly repair and recovery routines.

Senescent cells accumulate with age and contribute to chronic inflammatory signaling and tissue decline. Intermittent senolytic strategies are designed to selectively target these aged cells while allowing normal cells to remain unaffected.

Early human studies using intermittent senolytic combinations suggest that short, pulsed dosing can lower certain senescence-associated markers and is generally well tolerated. While still emerging, this evidence supports non-daily, structured pulse approaches. RESET applies this model using dietary flavonoids in a defined monthly two-day protocol.

In preclinical studies, intermittent fisetin reduced senescence-associated markers and improved measures of tissue function in aged animals. These findings have made fisetin one of the most studied dietary flavonoids in senescence research. While this evidence comes from laboratory and animal models, it provides the scientific basis for ongoing human investigations.

Quercetin is a plant-derived flavonoid that played a foundational role in early senolytic discovery research, including the identification of dasatinib + quercetin (D+Q) as a senolytic combination. In humans, quercetin has been studied for its anti-inflammatory and metabolic effects, and in enhanced-bioavailability forms (such as phytosome technology) it achieves substantially higher systemic exposure. Together, this body of research supports quercetin’s relevance in intermittent, pulse-based protocols.

Luteolin is a plant-derived flavonoid that modulates key inflammatory signaling pathways involved in the senescence-associated secretory phenotype (SASP). In preclinical models, it reduces pro-inflammatory cytokines and supports cellular resilience, complementing senolytic-focused ingredients.

Piperine, a compound from black pepper, helps the body absorb certain plant compounds more effectively. Human studies show it can significantly increase blood levels of polyphenols, making it useful in short, pulse-based formulas.

With age, senescent cells accumulate in human skin. These cells release inflammatory signals (known as the SASP) that are associated with collagen breakdown, impaired repair, and changes in the dermal matrix.

Chronic oxidative stress activates collagen-degrading enzymes (MMPs) and impairs fibroblast function, accelerating dermal matrix breakdown and contributing to wrinkles and loss of firmness. Managing cellular oxidative balance is foundational to preserving dermal structure.

SkinAx²™ combines grape polyphenols, melon SOD, zinc, and vitamin C to regulate oxidative signaling at the cellular level. Human data show improvements in elasticity, firmness, and radiance, supported by enhanced collagen synthesis and reduced collagen breakdown.

Reggenerate® delivers collagen I, V and X, elastin, hyaluronic acid, and glycosaminoglycans in their native biological architecture - not as hydrolyzed fragments, but as an intact matrix that skin cells recognize and respond to directly. At 300mg, clinical trials show improvements in firmness, elasticity, hydration, and barrier function that outperform hydrolyzed collagen at doses over 20 times higher.

Healthy skin depends on both internal hydration and an intact lipid barrier. Hyaluronic acid supports water retention within the dermal matrix, while ceramides reinforce the skin barrier, reducing transepidermal water loss. Together they support elasticity, smoothness, and visible skin resilience.

Astaxanthin localizes within cellular membranes, helping stabilize lipid structures and reduce oxidative stress associated with UV exposure and environmental damage. Human trials report improvements in elasticity, moisture, and wrinkle parameters.

Vitamin C is required for collagen formation and structural stability. It activates key enzymes that allow collagen fibers to mature and strengthen. It also contributes to antioxidant defense in skin cells, and higher intake is associated with improved measures of skin aging in human studies.