NAD⁺ powers cellular energy. VITALIZE supports your NAD⁺ reserve each morning for consistent daytime energy, focus, and long-term vitality.
Supports consistent energy throughout your day
Helps maintain focus and mental clarity
Aids post-workout recovery and next-day readiness
Built for long-term cellular health and vitality
From your 30s onward, NAD⁺ declines; by your 40s–50s it can be up to 50% lower—like running life on half a battery. With less NAD⁺, cells work harder for the same output: everyday tasks take more effort, recovery slows, and energy flattens.
That’s why VITALIZE is built for the daylight window—when your cells need energy most. It supports the entire NAD⁺ cycle—build, activate, preserve, recycle—so cells have the fuel and signals to run efficiently through the day. The result: steadier daytime energy, clearer focus, and momentum you can build on, while supporting healthier aging over time.
Pair with RENEW: At night, RENEW supports cellular clean-up (autophagy), mitochondrial maintenance, and antioxidant defense—so you wake recovered and ready. By day, VITALIZE supports NAD⁺ so cells have the energy to work efficiently—so daytime energy and focus feel steadier. Together, AM support and PM repair form a simple 24-hour rhythm.
Sources: [1-4, 6–7, 9–12] — See all references (tab 12).
How to take
Take 2 capsules each morning, with or without food. If fasting, take with your first meal. Aim for the same time every day.
Why morning
Daytime is when cells spend the most energy. A morning dose builds the NAD⁺ reserve ahead of demand and aligns with the circadian rhythm. It’s not a stimulant—think charging the battery, not flipping a switch. Benefits build with consistency.
Lifestyle protocol: AM routine
• Hydrate: 300–500 ml water before coffee to kick start cellular energy and circulation.
• Fuel: take VITALIZE with breakfast/first meal; include 20–30 g protein for steadier energy
• Light and movement: get 5–10 minutes of outdoor daylight within an hour of waking plus a short walk or stretch. This anchors your circadian clock and pairs with VITALIZE’s AM dosing.
Pairing
AM VITALIZE + PM RENEW = a simple 24-hour cellular routine.
Day: NAD⁺, sirtuins, and AMPK support.
Night: autophagy and mitochondrial maintenance.
Safety and usage
Intended for healthy adults. Not for pregnancy or breastfeeding.
Sources: [2–6]
Clinically studied ingredients
Together they support daytime cellular energy—build, activate, preserve, recycle—for steadier days and healthy aging over time.
Per daily serving (2 capsules):
Uthever® NMN — Build
(≥99% purity; 500 mg)
Direct NAD⁺ precursor—the building block for cellular energy and repair. Clinically studied.
Trans-Resveratrol — Activate
(From Japanese knotweed; 150 mg)
Supports NAD⁺-dependent sirtuins and AMPK signaling for efficient energy use and stress resilience; pairs with NMN.
Apigenin (ApiAge™) — Preserve
(From chamomile; 150 mg)
Helps temper CD38 (an NAD⁺-consuming enzyme) to support NAD⁺ availability.
TMG (Betaine) — Recycle
(150 mg)
Supports NAD⁺ recycling via the methylation cycle, helping maintain healthy NAD⁺ balance.
Pterostilbene — Activate
(From blueberries; 50 mg)
Resveratrol-family compound with higher bioavailability; complements resveratrol for broader sirtuin/AMPK coverage.
Piperine — Assist
(From black pepper; 20 mg)
Included to support the uptake of polyphenols.
Trademark notice: Uthever® is a registered trademark of Effepharm (Shanghai) Co., Ltd. ApiAge™ is a trademark of Effepharm (Shanghai) Co., Ltd.
Shipping
Worldwide delivery — 3–10 business days from dispatch (varies by region). See Shipping & Returns.
90 Day Guarantee
We’re confident you’ll feel the difference. Results build over 2–3 months. If you’re not satisfied, email support@cellaro.com within 90 days of delivery and we’ll refund one pouch from your first order — no return required.
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Made in Germany
Clinically studied ingredients
Third-Party Tested for Purity
Optimized Multi-Active Formulas
NAD⁺: Your Cells’ Hidden Energy Reserve
NAD⁺ is a molecule every cell in your body uses to produce energy, it’s your built-in cellular battery. From your 30s onward NAD⁺ levels decline; by midlife, levels are often ~50% lower.
Think of it as running on half a battery.
When NAD⁺ levels are low, you may notice:
- lower daily energy
- slower physical recovery
- reduced mental focus
- early changes in skin vitality
The good news: NAD⁺ levels are modifiable. With smart habits — and consistent support — you can rebuild your cellular energy reserve over time.
How Vitalize Works
A six-ingredient system that works synergistically to rebuild the NAD⁺ reserve.
Replenish – top up the NAD⁺ reserve
Preserve – reduce daily drain
Recycle – support your cells’ NAD⁺ recycling system
Direct – support sirtuins and AMPK, key maintenance pathways
Why this matters: by addressing all four levers, VITALIZE helps you make the most of NAD⁺ support—delivering steadier energy, clearer focus, more reliable recovery, and ongoing support for healthy aging.
Longevity Starts with Clarity: Measuring NAD⁺ Levels
Measure your NAD⁺ level with an at-home blood test. Get your baseline and benchmark ranges so you can make smarter choices.
You can always retest later to confirm progress.
Our Ingredients
Uthever® NMN
Directly boosts NAD⁺ levels, the essential building block for cellular energy and repair. Clinically studied, >99% pure.
Explore
Trans-Resveratrol
Activates NAD⁺-dependent sirloins and supports AMPK signaling for efficient energy use and stress resilience.
Explore
ApiAge™ Apigenin
Helps temper CD38 (an NAD⁺-consuming enzyme) to support NAD⁺ availability and protect against cellular stress.
Explore
TMG
Supports NAD⁺ recycling by fueling the methylation cycle — helping maintain healthy NAD⁺ balance.
ExploreSynergy Together: A Smarter Way to Support NAD⁺ Levels
First signs
Energy steadier
Improved mental clarity
Performance builds
Stamina lasts longer
Faster recovery
Compounded gains
Enhanced cellular function
Improved clarity & endurance
Build Your Longevity Routine
For foundational cellular health and repair
A structured system designed to support all 12 hallmarks of aging.
Longevity insights for cellular energy
Cellaro VITALIZE is a daily NAD⁺ support supplement designed to help maintain cellular energy, resilience, and metabolic function. It combines NMN with complementary compounds that support NAD⁺ production, recycling, and protection—so levels rise more efficiently and stay steadier across the day.
No. VITALIZE isn’t a stimulant and contains no caffeine. It supports cellular energy metabolism (via NAD⁺ pathways), which most people feel as steadier days, not a buzz or crash. You can still drink coffee; VITALIZE works on the cellular machinery that helps you run efficiently across the day.
NMN raises NAD⁺, but production is only part of the equation. Cellaro VITALIZE is designed as a multi-pathway system that supports NAD⁺ from several angles:
By addressing synthesis, preservation, and downstream signalling together, VITALIZE helps reduce biological bottlenecks and supports steadier NAD⁺ levels across the day, rather than relying on a single precursor alone.
Take VITALIZE every morning, ideally at the same time. With breakfast is simplest; if you fast, take it with your first meal. Coffee is fine. A little dietary fat may aid comfort/absorption of fat-soluble polyphenols. Training and rest days are both VITALIZE days, consistency is the point.
Raising NAD⁺ is step one. VITALIZE is a multi-pathway system: precursor (NMN), support for NAD⁺ breakdown and recycling, and polyphenols that engage repair signaling. This helps remove bottlenecks for a quicker ramp and steadier levels across the day, rather than relying on a single precursor that only addresses NAD⁺ production.
We recommend 500 mg daily (2 capsules) for a robust start; many see clearer changes by ~8 weeks. After re-testing, some maintain at 250 mg (1 capsule); others, especially active or 40+—stay at 500 mg. New to NMN? Start with 1/day for 1–2 weeks, then move to 2/day.
IV drips can create a short-lived spike and are time-intensive/costly. VITALIZE aims to build and stabilise your own NAD⁺ daily, is easier to sustain, and fits real life. If you’re considering IVs, measure, don’t guess, using the NAD⁺ blood test before and after to compare.
VITALIZE is stimulant-free and generally well tolerated. Rarely, mild stomach discomfort occurs; taking with food can help. If you’re pregnant, breastfeeding, have a medical condition, or take prescription medicines (especially anticoagulants), review the ingredients with your clinician before use.
Yes. Take a baseline NAD⁺ blood test before starting, then re-test in 8–12 weeks under similar conditions. You’ll see your number, reference range, and change over time, so you can confirm impact and fine-tune your plan.
NAD⁺ biology, aging, and circadian regulation
Human NMN supplementation and metabolic outcomes
4. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224–1229.https://doi.org/10.1126/science.abe9985 PubMed: https://pubmed.ncbi.nlm.nih.gov/34112603/
Clinical trial: NCT03151239
5. Irie J, Inagaki E, Fujita M, et al. Effect of oral NMN on clinical parameters in healthy men. Endocrine Journal. 2020;67(2):153–160.https://doi.org/10.1507/endocrj.EJ19-0313 PubMed: https://pubmed.ncbi.nlm.nih.gov/31685720/
6. Yi L, Maier AB, Tao R, et al. Efficacy and safety of β-NMN supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled trial. GeroScience. 2023;45(1):29–43. https://doi.org/10.1007/s11357-022-00687-2
PubMed: htps://pubmed.ncbi.nlm.nih.gov/36522692/
Clinical trial: NCT04823260
7. Huang H. Efficacy and safety of Uthever® NMN supplementation in middle-aged and older adults. Frontiers in Aging. 2022;3:851698.
https://doi.org/10.3389/fragi.2022.851698
PubMed: https://pubmed.ncbi.nlm.nih.gov/35769442/
Clinical trial: NCT04228640
NMN transport and NAD⁺ metabolism
8 Grozio A, Mills KF, Yoshino J, et al. SLC12A8 is a nicotinamide mononucleotide transporter. Nature Metabolism. 2019;1:362–370.
https://doi.org/10.1038/s42255-019-0042-4 PubMed: https://pubmed.ncbi.nlm.nih.gov/31745190/
9. Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD⁺ precursor vitamins. Annual Review of Nutrition. 2008;28:115–130.
https://doi.org/10.1146/annurev.nutr.28.061807.155443
PubMed: https://pubmed.ncbi.nlm.nih.gov/18429699/
10. Trammell SAJ, Schmidt MS, Weidemann BJ, et al. Nicotinamide riboside is orally bioavailable in mice and humans. Nature Communications. 2016;7:12948. https://doi.org/10.1038/ncomms12948
PubMed: https://pubmed.ncbi.nlm.nih.gov/27721479/
Apigenin, CD38 inhibition, and NAD⁺ preservation
11. Escande C, Nin V, Price NL, et al. Flavonoid apigenin is an inhibitor of the NAD⁺ase CD38. Diabetes. 2013;62(4):1084–1093.
https://doi.org/10.2337/db12-1139 PubMed: https://pubmed.ncbi.nlm.nih.gov/23223181/
12. Ogura Y, Kitada M, Xu J, et al. CD38 inhibition by apigenin restores intracellular NAD⁺/NADH ratio and SIRT3 activity. Aging (Albany NY). 2020;12(12):11325–11336. https://doi.org/10.18632/aging.103305 PubMed: https://pubmed.ncbi.nlm.nih.gov/32530826/
Bioavailability enhancers (piperine)
13. Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine inhibits human P-glycoprotein and CYP3A4. Journal of Pharmacology and Experimental Therapeutics. 2002;302(2):645–650.
https://doi.org/10.1124/jpet.102.034132
PubMed: https://pubmed.ncbi.nlm.nih.gov/12130723/
14. Shoba G, Joy D, Joseph T, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and humans. Planta Medica. 1998;64(4):353–356. https://doi.org/10.1055/s-2006-957450
PubMed: https://pubmed.ncbi.nlm.nih.gov/9619120/
Manufacturer data and disclosures
15. Uthever® NMN Stability Report (solid form). Manufacturer technical report; 2022.
16. Business Wire. “Effepharm’s Uthever® NMN clinical trial: NAD⁺/NADH increased ~38% at 60 days.” June 7, 2022.
https://www.businesswire.com/news/home/20220607005516/en/
17- ANSA.it (Business Wire syndication). “Uthever® NMN trial results announced.” June 7, 2022. https://www.ansa.it/english/news/business/2022/06/07/
