RESET
Your Monthly Cellular Reset.
8 capsules. 2 days. Once a month.
Senescent cells accumulate with age and release signals that burden healthy tissue. RESET is a targeted monthly protocol to support their natural clearance and promote long-term cellular resilience.
- Senescent-cell clean-up: reduces cellular burden that accumulates with age
- Calms age-related inflammatory signals: reduces background cellular stress
- Supports long-term cellular renewal: steadier recovery and resilience over time
Made in Germany ¡ GMP certified ¡ Third-party lab tested ¡ Vegan ¡ Gluten-free
With age, senescent cells accumulate. These worn-out cells stop dividing but persist, releasing pro-inflammatory signals that burden nearby healthy tissue and slow recovery. Over time, this build-up contributes to age-related decline.
RESET combines three complementary flavonoids at clinically researched doses: fisetin, quercetin (QuercefitÂŽ phytosome), and luteolin. Together they support the body's natural clearance of senescent cells while protecting the healthy cells you still need.
The 2-day monthly pulse protocol is informed by senolytic research from the Buck Institute and Mayo Clinic. The approach provides focused support during the pulse, then gives your body time to recover and remodel between cycles.
Standard Protocol: 4 capsules per day for 2 consecutive days, once per month. Take 2 capsules in the morning and 2 in the evening, with food.
Advanced Protocol: For periods of higher demand such as increased inflammation, heavy training, or high stress. Same daily dose, twice per month, spaced 12 to 14 days apart.
Many people begin with the Advanced Protocol, then transition to the Standard Protocol as their baseline stabilizes.
On pulse days: hydrate well, prioritize recovery movement, choose protein-forward meals, and avoid alcohol.
RESET is intended for healthy adults. Not for children, or for pregnant or breastfeeding women. If you take prescription medication or have a medical condition, consult your doctor before use. Do not take RESET daily.
Foundation senolytic
Fisetin (50% extract) â 1,000 mg
The most studied flavonoid for senescent cell clearance
Supports the body's natural clearance of aging senescent cells and helps ease background cellular stress. Published Mayo Clinic research identified fisetin as a senotherapeutic in vivo.
Synergistic senolytic
Quercetin QuercefitÂŽ phytosome â 500 mg
Enhanced absorption. Works across multiple senescence pathways.
The QuercefitÂŽ phytosome form provides roughly 20x better bioavailability than standard quercetin. QuercefitÂŽ is a registered trademark of Indena S.p.A.
Broad tissue coverage
Luteolin â 125 mg
Crosses the blood-brain barrier. Supports balanced inflammatory signaling.
A brain-penetrant flavonoid that extends RESET's senolytic coverage to neurological tissue.
Bioavailability enhancer
Black Pepper Extract piperine â 25 mg
Maximizes polyphenol absorption during the 2-day pulse
Supports uptake of all three flavonoids during the pulse window. Free from caffeine.
Free EU shipping on all orders. Worldwide delivery typically 3 to 10 business days, varies by region.
90-day money-back guarantee. If you are not satisfied, email hello@cellaro.com within 90 days of delivery and we will refund one pouch from your first order. No return required.
Subscriptions ship monthly and can be paused or cancelled anytime from your account.
Informed by senolytic research from the Mayo Clinic and Buck Institute ¡ QuercefitŽ is a registered trademark of Indena S.p.A.
The missing step in cellular renewal
RESET is a simple 2-day monthly protocol designed to support the body's natural removal of lingering senescent cells using clinically studied senolytic compounds.
Target - Senescent pathways
Natural senolytics (fisetin, quercetin, and luteolin) help identify senescent cells associated with chronic inflammation and age-related decline, without affecting healthy cells.
Clear - Support natural removal
These compounds work through complementary pathways that support the body's own clearance processes, helping reduce the accumulation of lingering cells.
Reset - Make space for renewal
Once cleared, the cellular environment can shift toward healthier turnover, supporting resilience, recovery, and long-term vitality.
The more senescent cells you have, the older your body behaves.
Senescent cells stop working but don't die. They release pro-inflammatory signals that stress neighbouring cells and accumulate with age â draining energy, slowing recovery, and contributing to age-related decline.
The mechanism
Senescent cells (often called "zombie cells") linger and release pro-inflammatory signals that stress nearby cells, like a moldy fruit spoiling the whole bowl. Preclinical research suggests that reducing this burden can help restore tissue function.
Inflammaging
As senescent cell burden rises with age, so does background inflammation. This process, known as inflammaging, contributes to slower recovery, lower energy, and visible changes in skin quality over time.
Why pulse? The smarter way to reset your cells.
RESET uses short, focused pulses, two days at a time, to target lingering senescent cells while minimising impact on healthy cells.
Monthly
For ongoing cellular renewal and healthy aging
2 consecutive days per month
2 capsules AM + 2 capsules PM
8 capsules total per month
Twice monthly
For higher inflammation, heavy training, or high-stress lifestyles
2 consecutive days, twice per month
2 capsules AM + 2 capsules PM
16 capsules total per month
| Week 1 | Week 2 | Week 3 | Week 4 | |
|---|---|---|---|---|
| Standard Protocol | 2 days AM + PM | â | â | â |
| Advanced Protocol | 2 days AM + PM | â | 2 days AM + PM | â |
Have questions about the protocol? See FAQ
Why it works
Three senolytics. One smarter protocol.
Standard senolytic supplements
One pathway. And most of the quercetin never arrives. Standard quercetin is poorly absorbed. Studies show as little as 1% reaches circulation. A 500mg label dose may deliver the effect of 5mg. RESET uses QuercefitÂŽ â a phytosome form of quercetin with approximately 20x better absorption than standard quercetin. Single-ingredient formulas also target only one senescence signal, leaving most of the burden untouched.
RESET
Three pathways. Fisetin targets the core senolytic pathway. QuercefitÂŽ phytosome delivers quercetin at 20x the bioavailability of standard quercetin. Luteolin crosses the blood-brain barrier, adding neurological coverage most formulas never reach.
Each targets a different aspect of senescence. Together the coverage is broader, the clearance is more complete.
The Formula
Four ingredients. One monthly cellular reset.
A plant-based senolytic stack designed for the 2-day monthly pulse protocol. Each ingredient has a specific role. Together they clear more than any single compound can.
Fisetin
Foundation senolytic
Read more
The most potent flavonoid for senescent cell clearance. Mayo Clinic research identified fisetin as a senotherapeutic in vivo. Supports full-body cellular renewal at 1,000 mg per pulse day.
Explore fisetin
QuercefitÂŽ Quercetin
Synergistic senolytic
Read more
Phytosome form for approximately 20x better absorption than standard quercetin. Complements fisetin across multiple senescence pathways while moderating oxidative and inflammatory signals.
Explore quercetin
Luteolin
Broad tissue coverage
Read more
Brain-penetrant flavonoid that extends RESET's coverage to neurological tissue. Supports balanced inflammatory signaling and antioxidant defenses beyond the periphery.
Explore luteolin
Piperine
Bioavailability enhancer
Read more
Maximises absorption of all three flavonoids during the pulse window, ensuring stronger results from each monthly protocol. Free from caffeine.
Explore piperineFour ingredients. One monthly pulse. Two days.
Start your monthly routineWhat happens after you start RESET.
Clean-up starts.
- Senolytic support begins
- Aged cells start clearing
- Some notice easier recovery after training
Clearance progresses.
- Senescent load declines
- Inflammatory tone calms
- Recovery feels steadier between pulses
Long-term renewal.
- Healthier cell turnover established
- Aging-related signals slow
- Energy and resilience feel more reliable
RESET clears the environment. BOOST builds the structure.
Senescent cells in the dermis release enzymes that actively degrade collagen. RESET supports their clearance. BOOST then delivers the building blocks collagen needs to form and last. Two different products. One coordinated approach to skin longevity.
Why RESET outperforms single-ingredient supplements.
What people ask before they order.
Everything you need to know about the RESET protocol, who it is for, and how it works.
Cellaro RESET is a short monthly supplement protocol designed to support the body's natural clearance of senescent cells. It uses a 2-day pulse rather than daily dosing, aligning with how senescent cells accumulate over time and how the body recovers between clearance phases. It contains fisetin, quercetin (QuercefitÂŽ phytosome), luteolin, and piperine for absorption.
Senescent cells are worn-out cells that stop dividing but don't die. They linger and release inflammatory signals that can disrupt nearby healthy cells. Over time they accumulate, slowing recovery and raising background cellular stress. Reducing that burden helps restore a healthier cellular environment so healthy cells can function more efficiently.
Standard RESET (once monthly): A 2-day pulse once per month. Best for ongoing cellular renewal and healthy aging. Ideal for long-term maintenance.
Advanced RESET (twice monthly): Two 2-day pulses per month, spaced about two weeks apart. For periods of higher demand such as increased inflammation, heavy training, or high-stress lifestyles.
Both protocols use the same daily dose. Only the frequency changes.
RESET uses pulsed senolytic support, periodic short protocols, rather than daily low dosing. Senescent cells accumulate gradually. Constant daily exposure is unnecessary and potentially counterproductive because senescent cells also play short-term protective roles in wound healing. The 2-day pulse provides focused support followed by recovery time, allowing the body to respond and rebalance. It is about precision, not caution.
Many people start with the Advanced Protocol to support an initial deeper reset, then transition to the Standard Protocol for ongoing maintenance once they feel balanced. RESET is intentionally flexible. Your protocol does not need to be permanent. Start where feels right and adjust based on how you feel over the following months.
Most users notice easier day-to-day recovery and less background fatigue within 4 to 8 weeks, with steadier effects after 2 to 3 months of monthly pulses. Responses vary by age, training load, sleep, and nutrition. Consistency matters more than the exact day of the month. Running the pulse on schedule is what builds the cumulative effect.
RESET and BOOST support skin health through different but complementary pathways. RESET reduces the burden of senescent cells in the dermis. These cells release MMP enzymes that actively degrade collagen. By clearing them, RESET creates a healthier cellular environment for skin renewal.
BOOST then delivers the structural building blocks collagen needs to form and last. RESET clears the environment. BOOST builds the structure. Together they address different layers of the same problem.
VITALIZE supports cellular energy and NAD+ pathways daily in the morning. RENEW supports nightly autophagy and cellular repair. RESET provides a monthly senolytic pulse to clear the accumulated cellular burden that the daily products cannot address. Together they support different phases of cellular health without overlapping daily stress.
Yes. RESET's pulse approach can be used alongside most nutrition and lifestyle routines. Keep your other supplements consistent across baseline and follow-up periods so you can assess changes. If you take prescription medicines or have a medical condition, consult your clinician before use.
Yes. Intense training increases cellular stress and senescent cells can accumulate in muscle and joint tissues. A monthly (or twice-monthly) pulse can support steadier recovery. If you have a hard training block or event, schedule pulses on lighter days. Always follow the product directions.
RESET is stimulant-free and generally well tolerated. A small number of people report mild, transient stomach discomfort during pulse days. Taking with food and adequate hydration helps. If you feel unwell, stop and consult your clinician. This is a food supplement, not a medical treatment.
Not intended for individuals under 18. If you are pregnant, breastfeeding, have a medical condition, or take medications, speak with your clinician before use. Not recommended during active cancer treatment unless advised by a clinician. Do not take RESET daily.
RESET is vegan-friendly and gluten-free to the best of our knowledge. It does not contain common allergens as ingredients. Always check the label for the latest allergen statement. If you have specific intolerances, consult your clinician before use.
Understand the science behind RESET.
Senescence ¡ 6 min read
Senescence 101: How senescent cells affect aging
Senescent cells stop dividing but don't die. They linger and release signals that disrupt healthy tissue. Here is what that means for how your body ages.
Read article
Inflammaging ¡ 5 min read
Inflammaging: How quiet inflammation accelerates aging
Chronic low-grade inflammation is not the same as acute inflammation. It builds silently with age and is closely linked to senescent cell burden.
Read article
Recovery ¡ 7 min read
Cellular Recovery for Athletes after 35
Hard training accelerates senescent cell accumulation in muscle and joint tissue. Here is how to build a cellular-level recovery protocol that keeps up.
Read articleKey clinical studies and references
Senescence biology and SASP
- Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nature Reviews Molecular Cell Biology. 2007;8(9):729â740. View on PubMed
- Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. The Journals of Gerontology: Series A. 2014;69(Suppl 1):S4âS9. View on PubMed
- Childs BG, et al. Senescent cells: an emerging target for diseases of ageing. Nature Reviews Drug Discovery. 2017;16(10):718â735. View on PubMed
Senolytics and intermittent dosing
- Baker DJ, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011;479(7372):232â236. View on PubMed
- Kirkland JL, Tchkonia T. Senolytic drugs: from discovery to translation. Journal of Internal Medicine. 2020;288(5):518â536. View Study
- Zhu Y, et al. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell. 2016;15(3):428â435. View Study
Human data on intermittent senolytic pulses
- Justice JN, et al. Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label pilot study. EBioMedicine. 2019;40:554â563. View on PubMed
- Hickson LJ, et al. Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease. EBioMedicine. 2019;47:446â456. View on PMC
- Nambiar A, et al. Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results from a randomized pilot trial. EBioMedicine. 2023. View on PubMed
Fisetin
- Yousefzadeh MJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18â28. View on PubMed
- Khan N, et al. Fisetin: a dietary antioxidant for health promotion. Antioxidants and Redox Signaling. 2013;19(2):151â162. View Study
- AFFIRM Frailty Trial (ongoing). Fisetin in older adults. ClinicalTrials.gov NCT03675724
Quercetin and QuercefitÂŽ
- Di Pierro F, et al. QuercefitÂŽ (quercetin phytosome): enhanced bioavailability (~20x) and improvements in antioxidant and inflammation markers. Minerva Medica. 2019;110(7):524â533. View on PubMed
- Riva A, et al. Improved oral absorption of quercetin from quercetin phytosome in healthy subjects. European Journal of Drug Metabolism and Pharmacokinetics. 2019;44(2):169â177. View Study
Luteolin
- Kou X, et al. Luteolin alleviates oxidative stress and cellular senescence via SIRT1/p53 pathway modulation. Free Radical Biology and Medicine. 2017;106:20â30. View on PubMed
- Luo Y, et al. Luteolin ameliorates neuroinflammation and memory impairment through microglial modulation. Frontiers in Aging Neuroscience. 2017;9:254. View on PubMed
Piperine and bioavailability
- Singh A, et al. Enhanced oral bioavailability of quercetin with piperine co-administration: preclinical evidence. Pharmacognosy Magazine. 2017;13(Suppl 2):S250âS256. View on PMC
- Shoba G, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica. 1998;64(4):353â356. View on PubMed
- Tripathi S, et al. Piperine as a bioenhancer: a review of preclinical and clinical pharmacokinetic evidence. European Journal of Drug Metabolism and Pharmacokinetics. 2022;47(2):127â141. View on PMC
Skin aging and cellular senescence
- Waaijer M, et al. The number of p16INK4a-positive cells is increased in aged human dermis. Aging Cell. 2012;11(4):722â725. View Study
- Pilkington S, et al. Senescent fibroblasts accumulate in human skin with aging and impair the tissue environment. Journal of Investigative Dermatology. 2021. View Study
- Wlaschek M, Scharffetter-Kochanek K. Senescent dermal fibroblasts and the aging skin extracellular matrix. Journal of Investigative Dermatology. 2021. View Study
RESET
From 327 kr/month ¡ 90-day guarantee