Longvida® is a clinically studied curcumin formulation designed to enhance absorption and support cellular recovery, mitochondrial resilience, and balanced inflammatory signaling—particularly during overnight repair processes.
Hallmarks supported: Altered Intercellular Communication · Mitochondrial Dysfunction · Loss of Proteostasis
What is Longvida® Optimized Curcumin®
Longvida® is a patented form of curcumin designed to help the body absorb and use curcumin more effectively. Instead of being quickly broken down and discarded, Longvida® delivers curcumin in a form that can circulate in the body at meaningful levels from a single daily dose.
Human and preclinical research on Longvida® spans recovery, inflammatory balance, cognition, and vascular function.
How Longvida® curcumin supports cellular processes
Curcumin influences inflammatory and oxidative signaling, but standard curcumin is poorly absorbed and rapidly inactivated after ingestion. Longvida® solves this by pairing curcumin with natural fats that help it pass through the gut and enter circulation intact, where it can remain available for longer.
This extended exposure supports overnight cellular recovery processes involved in inflammatory balance, antioxidant defenses, and mitochondrial resilience. Human pharmacokinetic studies show detectable free curcumin within about one hour, with measurable levels lasting across a 24-hour window—making it a strong fit for nighttime repair and recovery.
Pathways and outcomes studied
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Supports regulation of inflammatory signaling following physical stress, with reduced rises in markers such as CK, TNF-α, and IL-8 observed in controlled human trials
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Enhances systemic exposure to free curcumin compared with standard curcumin extracts, enabling consistent cellular signaling with once-daily dosing
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Studied in relation to antioxidant defenses, mitochondrial resilience, cognitive function, and vascular endothelial signaling in human and preclinical research
Why Longvida® curcumin is in RENEW
In the Cellaro system, Longvida® curcumin is included in RENEW to support nighttime repair and recovery processes. Sleep is a key window for cellular maintenance, inflammatory resolution, and tissue repair.
Longvida®’s extended exposure profile allows curcumin to remain active throughout the night, complementing other RENEW ingredients that support autophagy, mitochondrial health, and cellular renewal. Rather than acting as a short-lived antioxidant, Longvida® provides steady signaling support aligned with the body’s natural overnight recovery rhythms.
Dosage context
What RENEW provides
400 mg Longvida® curcumin per day (per 2-capsule serving).
What research uses
Human studies with Longvida® commonly use ~400 mg/day (either 1 × 400 mg or 2 × 200 mg). Some protocols explore higher totals, up to ~1,000 mg/day, depending on outcome and duration.
How this fits
400 mg is a practical, evidence-aligned daily dose chosen to support meaningful biomarker and functional readouts. Taken in the evening as part of RENEW, it aligns curcumin exposure with sleep and nightly recovery processes.
Why this isn’t just turmeric
Turmeric is a culinary spice that contains only a small fraction of curcumin, and standard curcumin extracts are poorly absorbed. Longvida® is engineered to deliver free curcumin with higher and more sustained exposure (onset ≈1 hour; detectable up to 24 hours).
This delivery profile helps explain why human studies at 400 mg/day observe measurable changes in inflammatory markers and recovery-related outcomes, which are difficult to achieve with turmeric or standard curcumin powders.
Research snapshot
Inflammatory recovery after physical stress
Longvida® curcumin has been studied in controlled human trials for post-exercise recovery and inflammatory signaling markers.
Sustained curcumin exposure in humans
Human pharmacokinetic studies suggest Longvida® delivers free curcumin into circulation with detectable exposure extending across a 24-hour window.
Cellular resilience and antioxidant signaling
Curcumin exposure has been studied in relation to oxidative and inflammatory signaling pathways that support cellular resilience and recovery.
FAQs
What’s the difference between Longvida® curcumin and regular curcumin?
Standard curcumin is poorly absorbed and is rapidly inactivated after ingestion, which often leads to low and short-lived blood levels.
Longvida® uses a patented lipid-based delivery system that allows curcumin to circulate as free (unconjugated) curcumin at practical daily doses. Human pharmacokinetic data show appearance within about one hour and measurable exposure across a 24-hour window, which is why 400 mg/day has been used in multiple studies.
How quickly does Longvida® curcumin act, and why take it at night?
Free curcumin from Longvida® appears in circulation within approximately one hour and remains detectable across a full 24-hour window in human studies.
An evening dose aligns this sustained exposure with sleep and RENEW’s overnight focus, supporting recovery, inflammatory balance, and cellular repair while you rest.