REGGENERATE™ provides naturally occurring collagen, elastin, and glycosaminoglycan components that support skin structure, elasticity, and visible smoothness.
Skin pathways supported: Dermal matrix support · Elasticity · Structural integrity
What is REGGENERATE™?
REGGENERATE™ is a purified French eggshell membrane ingredient that naturally contains key structural components found in the skin’s dermal matrix, including collagen types I, V, and X, elastin, hyaluronic acid, and sulfated glycosaminoglycans such as chondroitin, dermatan sulfate, and glucosamine.
Rather than supplying a single isolated protein, REGGENERATE™ delivers a ready-made dermal matrix complex that reflects how these components coexist in skin tissue and contribute to its structural integrity and elasticity.
REGGENERATE™ is a biobased, vegetarian-sourced eggshell membrane extract produced through a controlled, circular process. Its powdered membrane preserves a natural synergy of structural biomolecules aligned with the extracellular matrix of skin tissue.
Daily amount in BOOST: 300 mg
Allergen: Egg
Why we included it in BOOST
With age, the dermal matrix thins, elasticity declines, and the skin barrier becomes less efficient, leading to increased transepidermal water loss (TEWL) and visible changes in texture.
REGGENERATE™ was selected because it provides multiple complementary matrix components together, rather than relying on large doses of a single collagen source. Human clinical trials using eggshell membrane at 300 mg/day for 60 days report improvements in skin hydration, elasticity, and reductions in TEWL—signals consistent with a stronger, better-behaving skin barrier over time.
REGGENERATE™ is also produced from recycled French eggshells, supporting a circular sourcing approach that reduces waste compared with extractive marine or bovine collagen production.
Learn more about BOOST →
How it works
After ingestion, eggshell membrane components are digested into bioactive fragments that influence extracellular matrix renewal and water-handling pathways in the skin.
Providing collagen types I, V, and X alongside elastin and hyaluronic acid supports the dermal scaffold responsible for firmness and elasticity. Improvements in baseline hydration and matrix support are associated with lower TEWL, meaning the skin retains moisture more effectively.
Over time, this translates into skin that feels more resilient and looks smoother, particularly when paired with topical moisturiser and daily SPF.
How REGGENERATE™ differs from collagen powders
Most collagen supplements provide one or two collagen types in multi-gram doses, primarily contributing amino acids to general protein intake.
REGGENERATE™ takes a different approach. It supplies a naturally occurring dermal matrix complex at a lower, clinically studied dose. This matrix includes multiple collagen types, elastin, hyaluronic acid, and glycosaminoglycans—components that work together in skin structure.
Key differences:
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Matrix complexity vs. single collagen type
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Human data at 300 mg/day, not large scoop doses (5 - 10g)
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Focus on skin structure and barrier behavior rather than protein intake
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Designed for daily use alongside other skin-supporting nutrients
This makes REGGENERATE™ complementary to topical skincare and inside-out skin formulas like BOOST, rather than interchangeable with generic collagen powders.
Benefits
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Helps increase skin hydration and reduce transepidermal water loss (TEWL) over time
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Supports elasticity and the appearance of fine lines over 8–12 weeks
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Pairs naturally with hyaluronic acid, ceramides, vitamin C, and antioxidant polyphenols
Supplement vs. topical skincare
Topical products act on the skin’s surface and are essential for immediate comfort and protection. However, their effects depend partly on the condition of the underlying dermal matrix.
REGGENERATE™ works from within across living skin layers as the skin renews, supporting structural integrity and helping topical hydration last longer. The two approaches are complementary.
Use both: take BOOST daily and continue your usual serum and SPF routine.
Dosage context
What BOOST provides:
300 mg REGGENERATE™ per day (per 2-capsule serving)
What research uses:
Human trials commonly evaluate 300 mg/day for ~60 days, measuring hydration, TEWL, firmness, and elasticity.
How this fits:
300 mg/day aligns with skin-focused endpoints while keeping the formula balanced alongside hyaluronic acid, ceramides, vitamin C, and astaxanthin for inside-out support.
How REGGENERATE™ fits into the Cellaro skin system
REGGENERATE™ supports the structure of the dermal matrix, while SkinAx²™ Lift supports the processes that build and preserve collagen and elastin.
In BOOST, REGGENERATE™ provides the scaffold—collagen types I, V, and X, elastin, hyaluronic acid, and glycosaminoglycans—while SkinAx²™ Lift helps defend and support collagen fibers over time. Together, they form a coordinated inside-out approach to skin resilience, hydration, and elasticity.
Research snapshot (human data)
Impaired skin-barrier RCT (60 days, 300 mg/day)
Reported reductions in TEWL and improvements in firmness and elasticity versus placebo.
https://www.pulsus.com/scholarly-articles/ovodermsupsup-an-effective-treatment-to-improve-skin-condition-in-patients-with-altered-skin-barrier-function-4393.html
Healthy adults RCT (60 days, 300 mg/day)
Improvements in water loss, firmness, and elasticity compared with placebo.
https://symbiosisonlinepublishing.com/dermatology/dermatology80.pdf
Hair, skin, and nails RCT (12 weeks, 450 mg/day)
Reported improvements in hair density and peri-orbital wrinkle appearance.
https://pubmed.ncbi.nlm.nih.gov/31904175/
FAQs
What is the dermal matrix?
The dermal matrix is the skin’s internal scaffold, made primarily of collagen and elastin along with water-binding molecules such as hyaluronic acid and glycosaminoglycans. This matrix supports skin elasticity, firmness, and structural integrity. As it gradually degrades with age, the skin becomes less elastic and more prone to visible texture changes.
How is this different from generic collagen powders?
Generic collagen powders typically deliver one or two collagen types in multi-gram scoop doses (5–10 g), contributing primarily to overall protein intake.
Eggshell membrane takes a different approach. It is a naturally occurring dermal matrix that includes collagen types I, V, and X together with elastin, hyaluronic acid, and glycosaminoglycans. In human studies, eggshell membrane has been evaluated at 300 mg per day, assessing outcomes such as skin hydration, transepidermal water loss (TEWL), and elasticity.
These formats serve different purposes and reflect different formulation strategies: bulk collagen supplementation versus a concentrated, matrix-based ingredient designed for targeted skin support.
Does it really help the skin barrier?
Human studies evaluating eggshell membrane report reductions in transepidermal water loss (TEWL) alongside changes in hydration and elasticity parameters. Lower TEWL generally reflects a skin barrier that retains moisture more effectively, which is an important marker of skin barrier function.