A plant-based compound studied for its dual impact on aging cells and cognitive resilience.
Hallmarks supported: Inflammatory Signaling · Cellular Communication
What is Luteolin?
Luteolin is a naturally occurring flavonoid found in plants such as parsley, celery, and chamomile. Traditionally used in herbal wellness practices, luteolin is now studied for its role in inflammatory signaling, cellular communication, and brain-relevant aging pathways.
Notably, luteolin has been shown to cross the blood–brain barrier, which is why it is frequently discussed in the context of neuroinflammatory signaling and age-related changes within the nervous system.
How Luteolin supports cellular processes
Luteolin is studied for its ability to modulate inflammatory and stress-related signaling pathways that influence how aging cells behave. In preclinical and mechanistic research, luteolin has been shown to reduce pro-inflammatory signals and support antioxidant defenses, helping create a more balanced cellular signaling environment.
Within the nervous system, luteolin has been investigated for its effects on microglial activation and neuroinflammatory pathways, which are closely linked to cognitive aging and neural resilience. These properties make luteolin a complementary component in short, targeted protocols designed to address age-related cellular stress.
Pathways and outcomes studied
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Neuroinflammatory signaling: modulation of microglial activation and inflammatory pathways (preclinical)
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Cellular communication: support for balanced signaling environments under inflammatory stress
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Antioxidant pathways: contribution to endogenous antioxidant defenses
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Senescence-relevant biology: complementary mechanisms studied alongside other flavonoids
Why it’s in RESET
RESET is designed as a short, monthly pulse to address aging-related cellular processes that accumulate over time. Luteolin is included because it is studied for brain-relevant inflammatory signaling and cellular communication pathways that complement senescence-focused compounds.
In RESET, luteolin is paired with fisetin and quercetin (Quercefit® Phytosome) to broaden pathway coverage. While fisetin and quercetin are studied primarily in senescence and antioxidant contexts, luteolin contributes additional support for neuroinflammatory and signaling balance within the same short protocol window.
Research snapshot
Neuroinflammatory signaling and microglial activity
Preclinical research indicates that luteolin modulates microglial activation and inflammatory signaling in the nervous system, contributing to neuroprotective signaling patterns.
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Antioxidant and senescence-relevant pathways
Studies support luteolin’s role in antioxidant defense and cellular stress pathways that complement other senescence-focused flavonoids.
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FAQs
Can luteolin be taken daily?
Luteolin is commonly consumed in foods and is studied in daily-use contexts for inflammatory balance. In senescence-focused protocols like RESET, it is used intermittently to align with short, targeted approaches rather than continuous daily dosing.
Is luteolin safe?
Luteolin is found naturally in many foods and has demonstrated a favorable safety profile in preclinical research. As with any supplement, consult your clinician if you take medications or manage health conditions.
Why combine luteolin with fisetin and quercetin?
These compounds are studied for complementary roles across senescence biology, antioxidant defense, and inflammatory signaling. Together, they broaden pathway coverage within a short, coordinated protocol.