A well-studied polyphenol supporting cellular signaling and daytime resilience in VITALIZE.
Hallmarks supported: Epigenetic Alterations · Mitochondrial Function · Inflammatory Signaling
What is trans-resveratrol?
Trans-resveratrol is a polyphenol found in grapes and certain plants. It is studied for how it interacts with cellular stress-response pathways, including sirtuin-related signaling, and for its role in supporting healthy aging processes.
How trans-resveratrol supports cellular processes
Trans-resveratrol is studied for how it interacts with cellular signaling pathways involved in energy regulation, stress response, and maintenance. Research has explored its relationship with AMPK and sirtuin-linked networks, as well as antioxidant response pathways that help cells manage oxidative by-products. In practical terms, this signaling context is associated with mitochondrial function, gene regulation, and inflammatory balance during the day.
Pathways and outcomes studied
-
Supports sirtuin-related signaling associated with cellular maintenance and mitochondrial efficiency
-
Supports endogenous antioxidant defense pathways
-
Supports healthy endothelial function and vascular tone
Quality and stability
Identity and purity
We specify trans-resveratrol with tight analytical controls to verify identity and purity. Rigorous testing helps ensure consistency from batch to batch.
Stability over time
Trans-resveratrol can be sensitive to heat, light, and moisture. Quality manufacturing and packaging practices are designed to preserve stability throughout shelf life.
How trans-resveratrol fits into a daily routine
In daily longevity routines, trans-resveratrol is commonly used in the morning alongside NAD⁺ precursors such as NMN to support cellular signaling pathways involved in energy regulation, stress response, and healthy aging. It is often paired with related polyphenols such as pterostilbene, which has different absorption and tissue distribution characteristics, helping extend coverage across the day. In VITALIZE, trans-resveratrol is combined with pterostilbene and supportive nutrients to complement NAD⁺ metabolism and reinforce daytime cellular efficiency.
Dosage context
What VITALIZE provides: 150 mg per day.
What research uses: Human studies commonly use doses in the range of approximately 100–500 mg per day. Oral exposure is limited by rapid metabolism, which is why VITALIZE includes black pepper extract to support absorption. Read more →
What this means for you: 150 mg sits within the studied human range and is selected for consistent daily use as part of a longer-term routine. Rather than pushing toward the upper end, the dose is designed to complement NMN-driven NAD⁺ support and pterostilbene’s longer tissue persistence for steady daytime coverage.
Research snapshot
People-tested absorption (blood levels over time)
Resveratrol is rapidly metabolized. Some studies have explored whether co-administration with piperine may increase circulating exposure at the same dose.
Read the incidence study on resveratrol metabolism
Sirtuin and energy networks (preclinical/human-context)
Resveratrol has been studied in relation to AMPK–SIRT1 signaling pathways linked to mitochondrial function and cellular maintenance.
Read the AMPK–SIRT1 signaling review
See more clinical evidence →
FAQs
Is resveratrol the same as pterostilbene?
They’re closely related polyphenols but behave differently in the body. Tran-resveratrol has a broad and well established research base, while pterostilbene tends to last longer and move across cell membranes more easily. Used together they provide complementary daytime coverage.
Do I need to drink red wine to get resveratrol?
No. Wine contains variable and generally small amounts of resveratrol. A standardized trans-resveratrol serving provides a predictable intake without alcohol and fits more easily into a structured daily routine.Should I take it with food?
You can take VITALIZE as directed on the label. Food timing isn’t critical for resveratrol’s role in this formula. It is designed to be taken in the morning alongside other VITALIZE ingredients that support daytime cellular efficiency.
Is trans-resveratrol safe to take daily?
Trans-resveratrol is generally well tolerated at typical supplement amounts. If you take medications or manage health conditions, it’s sensible to check with your clinician before starting any new routine. As with any supplement, monitor how you feel and follow label guidance.