A daytime flavonoid studied for moderating CD38 activity and supporting NAD⁺ availability and cellular maintenance as part of VITALIZE.
Hallmarks Supported: Epigenetic Alterations · Deregulated Nutrient Sensing · Cellular Communication
What is apigenin?
Apigenin is a naturally occurring flavonoid found in plants such as chamomile, parsley, and celery. It has been studied for its role in regulating enzymes and signaling pathways involved in cellular maintenance, including CD38, an enzyme that consumes NAD⁺, as well as pathways linked to calm focus and stress regulation.
How apigenin supports cellular processes
As we age, certain immune and inflammatory signals can increase activity of CD38, one of the body’s main NAD⁺-consuming enzymes. Higher CD38 activity is associated with lower cellular NAD⁺ availability, which can limit downstream maintenance processes such as sirtuin signaling and mitochondrial support.
Apigenin has been studied in preclinical models for its ability to moderate CD38 activity, helping preserve NAD⁺ availability so routine cellular upkeep can run more efficiently during the day.
Separately, apigenin is also known from chamomile research for interacting with GABA-A receptors. This is associated with calm, composed focus rather than stimulation, supporting a steady daytime rhythm.
Pathways and outcomes studied
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Moderates CD38 activity linked to age-related NAD⁺ decline
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Helps preserve NAD⁺ availability for sirtuin-related cellular maintenance
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Supports calm focus via GABA-related signaling pathways
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Contributes antioxidant and anti-inflammatory support observed in flavonoid research
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CD38 rises with age while NAD⁺ tends to fall
Age-related increases in CD38 enzymatic activity are associated with lower cellular NAD⁺. Moderating CD38 through studied flavonoids like apigenin may support NAD⁺ availability for maintenance pathways.
Conceptual trend: As age increases, CD38 enzyme activity rises, which tends to correlate with lower intracellular NAD⁺. Apigenin has been studied for moderating CD38 activity in models, which may help preserve NAD⁺ availability and downstream maintenance pathways.
How apigenin fits into a daily longevity system
In the Cellaro system, apigenin is not used as a standalone calming ingredient. It is included in VITALIZE to help protect NAD⁺ availability during the day, complementing NAD⁺ precursors such as NMN and polyphenols such as resveratrol and pterostilbene.
By moderating CD38 activity, which consumes NAD⁺, and supporting a composed, non-stimulating rhythm, apigenin helps reinforce daytime cellular efficiency as part of a combined longevity routine.
Explore VITALIZE→
Dosage
What VITALIZE provides
150 mg apigenin per day.
What research uses
Human and preclinical studies explore a range of doses depending on context. In VITALIZE, apigenin is used to support NAD⁺ preservation and calm focus within a multi-ingredient system rather than as a high-dose single compound.
What this means for you
150 mg is selected to complement daytime NAD⁺ support and polyphenol signaling as part of a balanced daily routine.
Research snapshot
CD38 and age-related NAD⁺ decline
CD38 activity increases with age and contributes to declining NAD⁺ levels in cells. Moderating CD38 has been shown in models to help preserve NAD⁺ availability and mitochondrial function.
Apigenin and CD38 modulation
Apigenin has been studied as a natural CD38 inhibitor in experimental settings, supporting NAD⁺ preservation and downstream maintenance pathways.
Apigenin and calm focus
Research on chamomile and apigenin points to interactions with GABA-A receptors associated with calm, non-sedating effects.
FAQs
Is apigenin sedating?
No. Apigenin is associated with calm, composed focus rather than sedation. While chamomile is often linked with sleep rituals, apigenin itself has been studied for supporting relaxed alertness and cellular maintenance during the day. In VITALIZE, it is included to support daytime balance, not sleep.
How does apigenin help NAD⁺?
Apigenin has been studied for moderating CD38, an enzyme that consumes NAD⁺. By helping limit excessive NAD⁺ breakdown, apigenin supports the availability of NAD⁺ for downstream processes such as sirtuin signaling and cellular maintenance. This complements NAD⁺ precursors like NMN in a combined daily routine.Can I just drink chamomile tea?
Chamomile tea contains apigenin, but amounts vary widely depending on the plant, preparation, and serving size. A standardized apigenin ingredient provides a consistent, predictable amount designed to fit a structured daytime longevity routine.