A close cousin of resveratrol with a structure that allows it to stay in the body longer and move more easily across cell membranes, supporting sirtuin activity, mitochondrial function, and endogenous antioxidant defenses.
Hallmarks supported: Epigenetic Alterations · Mitochondrial Function · Inflammatory Signaling
What is pterostilbene?
Pterostilbene is a naturally occurring polyphenol found in blueberries and grapes. It is closely related to resveratrol, but its chemical structure makes it more fat-soluble and more resistant to rapid breakdown. As a result, pterostilbene tends to persist longer in the body, supporting sustained cellular signaling.
How pterostilbene supports cellular processes
Rather than acting as a one-off antioxidant, pterostilbene helps activate the body’s own cellular maintenance systems. It has been studied for its interaction with key pathways involved in energy regulation and cellular resilience, including AMPK, sirtuin-related signaling, and the NRF2 antioxidant response.
In practical terms, this supports steadier mitochondrial function, orderly cellular maintenance, and a balanced inflammatory response during the day.
Pathways and outcomes studied
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Supports sirtuin-related signaling linked to mitochondrial efficiency and cellular upkeep
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Activates endogenous antioxidant defenses via NRF2-associated pathways
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More stable and longer-lasting exposure than resveratrol in many models
How pterostilbene fits into a daily longevity system
In the Cellaro system, pterostilbene is not used as a standalone polyphenol. It is included in VITALIZE alongside trans-resveratrol and NAD⁺-supporting compounds to provide complementary daytime coverage.
Resveratrol has a broad and well-established evidence base but is metabolized relatively quickly. Pterostilbene’s greater stability and cell-membrane affinity help extend signaling over time. Together, they support the same cellular maintenance networks from different angles, reinforcing consistent daytime efficiency rather than relying on a single compound.
Dosage context
What VITALIZE provides
50 mg pterostilbene per day.
What research uses
Human studies have explored doses roughly in the range of 50–150 mg per day, depending on context. In VITALIZE, pterostilbene is used as a complementary component alongside resveratrol rather than as a high-dose standalone ingredient.
What this means for you
50 mg is selected to support steady daytime cellular signaling and durability when paired with resveratrol and NAD⁺-supporting compounds.
Food vs. supplement
Pterostilbene occurs naturally in blueberries and grapes, but dietary intake is typically low and variable. A standardized supplement provides a predictable amount that fits cleanly into a structured daily longevity routine.
Research snapshot
Sirtuin and energy networks
Pterostilbene has been studied for its interaction with AMPK–SIRT1 pathways linked to mitochondrial function and everyday cellular maintenance.
Endogenous antioxidant defenses
Research shows pterostilbene activates NRF2-related pathways, supporting the body’s own antioxidant systems rather than supplying direct antioxidants alone.
FAQs
What is pterostilbene, in simple terms?
It’s a blueberry-derived compound related to resveratrol that lasts longer in the body and supports the same cellular maintenance pathways.
Why include pterostilbene if VITALIZE already contains resveratrol?
They are closely related but not duplicates. Resveratrol provides breadth of evidence, while pterostilbene offers greater stability and persistence. Together they provide more consistent daytime support.
Is pterostilbene better absorbed than resveratrol?
It is generally more fat-soluble and more stable, which often translates to longer functional exposure. The goal is complementary coverage, not choosing one over the other.
Does black pepper extract support pterostilbene?
Yes. A small amount is included in VITALIZE to support the oral exposure of select polyphenols such as resveratrol and pterostilbene.