TMG (trimethylglycine) is a compound your body uses to keep cellular processes running smoothly. It is found naturally in beets, spinach, and whole grains, but most people do not get consistent amounts from food alone. Its main job is donating methyl groups — a resource your body needs for hundreds of daily tasks, including maintaining the systems that produce and recycle energy at the cellular level.

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How TMG supports cellular processes

Think of methyl groups as a consumable resource. Your body uses them constantly, and when you are actively supporting NAD+ levels, the demand goes up. TMG replenishes that resource so the rest of the system can keep running. Without it, the very processes you are trying to support can slow down.

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Pathways and outcomes studied

• Supports methyl balance when the body's demand is higher than usual
• Supports healthy breakdown of homocysteine, a compound that accumulates when methylation is under-resourced
• Supports the daily recycling of NAD+ so levels hold steady throughout the day

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Why TMG is in VITALIZE

Here is something most NAD+ brands do not mention. When your body converts NMN into NAD+ and then processes it, the breakdown uses up methyl groups from your own reserves. If those reserves are not being replenished, they get quietly depleted over time.

The result: NAD+ goes up, but you feel flat. Sometimes more tired than before. This is one of the main reasons people take NAD+ supplements for months and say they felt nothing, or felt worse. The supplement worked on paper. But the methylation cost cancelled the benefit.

TMG is in VITALIZE to prevent exactly this. It replenishes methyl groups as they are used, keeping the whole system in balance so that the NAD+ increase actually shows up as something you notice.

See the full VITALIZE formula

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Dosage context

What VITALIZE provides
150 mg TMG per day.

What research uses
 Studies have tested a range of doses. Lower amounts, like the dose in VITALIZE, are commonly used to maintain methyl balance alongside a daily NAD+ routine rather than as a standalone supplement.

What this means for you
150 mg is enough to support the methylation cycle daily without overdoing it. It is designed to work as part of the complete VITALIZE formula, not on its own.

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Research snapshot

Why NAD+ supplementation increases methyl demand
When your body breaks down NAD+, it produces a byproduct called methylated nicotinamide. That process draws on your methyl reserves. Research confirms this is a real and meaningful demand, which is why including a methyl donor alongside a NAD+ precursor makes practical sense.

Homocysteine and methylation
When methyl groups run low, homocysteine can accumulate. TMG has been studied specifically for its role in keeping homocysteine levels in a healthy range by supporting its conversion back into useful compounds.

See more clinical evidence

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FAQs

What is TMG and why is it used in NAD⁺ supplements?

TMG (trimethylglycine, also called betaine) is a methyl donor that supports one-carbon metabolism. When NAD⁺ levels are supported during the day, the body processes more nicotinamide, which places demand on methylation pathways. TMG helps maintain methyl balance so NAD⁺-related energy and repair processes can run smoothly as part of a combined routine.

Is TMG the same as folate or vitamin B₁₂?

Not the same, and not interchangeable. B vitamins support methylation through one route. TMG supports it through a separate, more direct route - and this is the route that comes under pressure when you are taking a NAD+ precursor like NMN. A B vitamin does not cover that demand. TMG does. That is why it is in VITALIZE and a B vitamin is not. 

Can I get enough TMG from food alone?

TMG is found in foods such as beets, spinach, and whole grains, but intake varies widely day to day. Supplemental TMG provides a consistent, predictable amount that fits cleanly into a structured daily NAD⁺ routine like VITALIZE, without relying on dietary variability.