What is Fisetin?

Fisetin is a naturally occurring flavonoid found in fruits such as strawberries, apples, cucumbers, and onions. Beyond its antioxidant activity, fisetin is widely studied in the context of cellular senescence, where it has been investigated for its ability to support the body’s handling of aged, dysfunctional (“senescent”) cells that accumulate with age and contribute to low-grade inflammation.

How Fisetin supports cellular processes

Senescent cells persist by activating survival pathways that allow them to resist normal self-clearance. In preclinical research, fisetin has been studied for its ability to influence these pathways when used intermittently. Short “pulse” exposures have been shown to reduce markers of senescence across multiple tissues in aged models, with effects that persist beyond the dosing window.

Human adipose tissue explant studies (ex vivo) have also reported reduced senescence markers and lower inflammatory signaling following brief fisetin exposure. Together, this research underpins the use of fisetin in short, targeted protocols rather than continuous daily supplementation.

Pathways and outcomes studied

• Cellular senescence pathways: reduced senescence markers in multiple tissues (preclinical)

• Inflammatory signaling: lower pro-inflammatory signals in human adipose tissue explants (ex vivo)

• Tissue communication: support for healthier cellular signaling environments

• Intermittent senolytic protocols: investigated as a foundation for pulse-based approaches (human trials ongoing)

Why it’s in RESET

RESET is designed as a short, monthly pulse to support aging-related cellular processes that accumulate over time. Fisetin is included because senescence-focused research typically evaluates senolytics using brief, intermittent dosing windows rather than daily use.

In RESET, fisetin is combined with quercetin (Quercefit® Phytosome) and luteolin to broaden pathway coverage. Quercetin is studied for complementary senescence and antioxidant pathways, while luteolin is studied for its role in inflammatory and cellular signaling balance. Together, the combination supports a system-level approach within a simple two-day monthly cadence.

Dosage context

What RESET provides
1,000 mg fisetin per protocol day, used in a short two-day pulse (1–2× per month), taken with food.

What research is exploring
Human senescence-focused protocols commonly evaluate approximately 20 mg/kg/day for two consecutive days, repeated intermittently (for example, every 14–30 days).

What preclinical work has shown
In aged models, brief fisetin exposure reduced senescence markers across multiple tissues and improved healthspan, with some studies also reporting lifespan extension.

What this means for you
RESET’s two-day pulse aligns with how senolytics are being studied: short, targeted windows rather than chronic daily dosing. Always follow label directions and consult your clinician if you have questions.

Fisetin reduces senescence markers in aged models (preclinical)

In a preclinical study in aged mice, intermittent fisetin lowered senescence-associated markers compared with untreated aged controls. This “pulse” pattern is one reason fisetin is most often discussed in short, targeted protocols rather than daily use.

Research snapshot

Senescence markers and inflammatory signaling
In preclinical and ex vivo human adipose tissue studies, fisetin reduced markers of cellular senescence and lowered inflammatory signaling following brief exposure.
Read more → 

Human trials (ongoing)
Intermittent senolytic regimens, such as approximately 20 mg/kg/day for two consecutive days, are currently being evaluated for functional outcomes and biomarker changes in humans.
Read more →
Explore clinical studies →

FAQs

Can fisetin be taken daily?

For senescence-focused goals, research is exploring intermittent, higher-dose pulses rather than daily micro-dosing. Daily fisetin is being studied for other effects, which is distinct from senolytic research.

Is fisetin safe?

Fisetin has shown a favorable safety profile in preclinical research and is currently being evaluated in controlled human trials. Always follow label directions and consult your clinician if you have medical conditions or take medications.

Why combine fisetin with quercetin and luteolin?

These compounds are studied for complementary roles across senescence biology, inflammatory signaling, and antioxidant defense, helping broaden pathway coverage beyond a single molecule.